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Titolo:
HORMONAL SUBSTITUTION IN OLDER MEN
Autore:
PUGEAT M; FIMBEL S; CRAVE JC; DECHAUD H; LEJEUNE H;
Indirizzi:
HOP ANTIQUAILLE,CLIN ENDOCRINOL LAB,1 RUE ANTIQUAILLE F-69321 LYON FRANCE HOP DEBROUSSE,INSERM,U329 LYON FRANCE HOP DEBROUSSE,INSERM,U307 F-69322 LYON FRANCE
Titolo Testata:
Hormone research
fascicolo: 1-3, volume: 43, anno: 1995,
pagine: 104 - 110
SICI:
0301-0163(1995)43:1-3<104:HSIOM>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GROWTH-HORMONE; SERUM DEHYDROEPIANDROSTERONE SULFATE; HUMAN CHORIONIC-GONADOTROPIN; SOMATOMEDIN-C LEVELS; SEX-STEROID-BINDING; LUTEINIZING-HORMONE; AGING MEN; INSULIN RESISTANCE; ADRENAL ANDROGENS; DIABETIC MICE;
Keywords:
ANDROGENS; GROWTH HORMONE; DEHYDROEPIANDROSTERONE, SULFATED; HORMONAL SUBSTITUTION; AGING MALE; INSULIN RESISTANCE; SEX HORMONE-BINDING GLOBULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
88
Recensione:
Indirizzi per estratti:
Citazione:
M. Pugeat et al., "HORMONAL SUBSTITUTION IN OLDER MEN", Hormone research, 43(1-3), 1995, pp. 104-110

Abstract

The biological bases of endocrine alterations in ageing men are now well identified: progressive impairment of testicular function, declinein growth hormone (GH) secretion with decreased insulin-like growth factor-I (IGF-T) levels, and reduced adrenal androgen secretion. Insulin resistance and glucose intolerance also accompany male ageing. The mechanisms of these age-related changes are still unknown. There are preliminary results on the effects of hormonal replacement therapy in older males with mild hypogonadism or decreased IGF-I levels. Controlledplacebo studies will in the future define the risks and benefits of long-term administration of androgens, GH or GH-releasing hormone in these patients. In view of the severe potential side effects, the generalized use of hormonal substitution in elderly men cannot, for the moment, be recommended.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:29:31