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Titolo:
PARAFFIN SECTION IMMUNOHISTOCHEMISTRY AS AN ADJUNCT TO MORPHOLOGIC ANALYSIS IN THE DIAGNOSIS OF CUTANEOUS LYMPHOID INFILTRATES
Autore:
RITTER JH; ADESOKAN PN; FITZGIBBON JF; WICK MR;
Indirizzi:
WASHINGTON UNIV,BARNES HOSP,MED CTR,DIV SURG PATHOL,BOX 8118,1 BARNESHOSP PLAZA ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT PATHOL ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT DERMATOL ST LOUIS MO 63110
Titolo Testata:
Journal of cutaneous pathology
fascicolo: 6, volume: 21, anno: 1994,
pagine: 481 - 493
SICI:
0303-6987(1994)21:6<481:PSIAAA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; CELL NUCLEAR ANTIGEN; B-CELL; EMBEDDED TISSUES; FLOW-CYTOMETRY; LYMPHOPROLIFERATIVE DISORDERS; FOLLICULAR HYPERPLASIA; LYMPHOCYTIC INFILTRATE; MONOCLONAL-ANTIBODIES; LUPUS-ERYTHEMATOSUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J.H. Ritter et al., "PARAFFIN SECTION IMMUNOHISTOCHEMISTRY AS AN ADJUNCT TO MORPHOLOGIC ANALYSIS IN THE DIAGNOSIS OF CUTANEOUS LYMPHOID INFILTRATES", Journal of cutaneous pathology, 21(6), 1994, pp. 481-493

Abstract

In the skin, separation of selected lymphomas from lymphoid hyperplasia can be challenging. The authors examined 45 cutaneous lymphomas, excluding mycosis fungoides (26 small lymphocytic or mixed tumors; 19 large cell lymphomas), 10 ''atypical'' lesions, and 40 lesions of presumed lymphoid hyperplasia, comparing morphologic attributes of such proliferations with their immunophenotypes in paraffin sections. The object of this study was to determine whether immunologic data obtained from routinely-processed specimens could be used to further objectify morphologic interpretations. Features favoring lymphoma included a lesional epicenter in the lower dermis or subcutis; poor circumscription of lymphoid aggregates; and dissection of lymphoid cells between collagenbundles. Immunostains included antibodies to CD20, CD43, CD45, CD45RO, CD45RA, CD68, proliferating cell nuclear antigen (PCNA), and MB2. Eleven of 26 small lymphocytic or mixed-cell lymphomas and 3 of 10 ''atypical'' cases demonstrated an abnormal immunophenotype, including co-expression of CD43 and CD20 or non-physiological CD45RA distribution. In contrast, none of 40, cases with benign features manifested aberrantantigen expression. Thirty-one of 37 cases in which greater than or equal to 75% of the cells typed as B lymphocytes showed malignant morphologic features, 5 were ''atypical'' and possibly lymphomatous, and only one had benign features. PCNA stains showed greater positivity of the lymphoid nuclei in lymphomas, and a labeling index of >30% was correlated with malignancy in this context. These observations indicate that immunostaining may provide useful adjunctive information in distinguishing benign from malignant cutaneous lymphoid proliferations in paraffin sections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:14:52