Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NO FURTHER IMPROVEMENT OF ISCHEMIC MYOCARDIAL-METABOLISM BY COMBININGPRECONDITIONING WITH BETA-BLOCKADE - AN IN-VIVO EXPERIMENTAL-STUDY INTHE PIG-HEART USING A MICRODIALYSIS TECHNIQUE
Autore:
WIKSTROM BG; RONQUIST G; WALDENSTROM A;
Indirizzi:
UMEA UNIV HOSP,DEPT CARDIOL S-90185 UMEA SWEDEN UMEA UNIV HOSP,DEPT CARDIOL S-90185 UMEA SWEDEN UNIV UPPSALA HOSP,DEPT CARDIOL UPPSALA SWEDEN UNIV UPPSALA HOSP,DEPT CLIN CHEM UPPSALA SWEDEN
Titolo Testata:
Acta Physiologica Scandinavica
fascicolo: 1, volume: 159, anno: 1997,
pagine: 23 - 32
SICI:
0001-6772(1997)159:1<23:NFIOIM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-ENERGY PHOSPHATES; CORONARY-OCCLUSION; RAT-HEART; INFARCT SIZE; ISCHEMIA; REPERFUSION; PROTECTION; GLUCOSE; INJURY; LIMIT;
Keywords:
ADENOSINE; BETA-BLOCKER; HEART; LACTATE; MICRODIALYSIS; PRECONDITIONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
B.G. Wikstrom et al., "NO FURTHER IMPROVEMENT OF ISCHEMIC MYOCARDIAL-METABOLISM BY COMBININGPRECONDITIONING WITH BETA-BLOCKADE - AN IN-VIVO EXPERIMENTAL-STUDY INTHE PIG-HEART USING A MICRODIALYSIS TECHNIQUE", Acta Physiologica Scandinavica, 159(1), 1997, pp. 23-32

Abstract

Adenine nucleotides, lactate and oyruvate were monitored by microdialysis in pig hearts, comprising four experimental groups. Two preconditioner groups, one beta-blocked by metoprolol (0.3 mg kg(-1) body wt. n= 6) and the other (n = 7) without beta-blockade. Two groups were notpreconditioned. one beta-blocked (n = 6) and one without beta-blockade (n = 7). Probes were inserted into ischaemic and non-ischaemic myocardium. Preconditioning consisted of four consecutive 10 min periods oiischaemia each separated by 20 min of reperfusion. Ali animals were subjected to 40 min oi index ischaemia followed by 25 min of reperfusion. Myocardial cAMP content was determined in biopsies after the final reperfusion and was found low in the beta-blocked groups. Lactate levels during index ischaemia exceeded the basal level 4-6-fold in dialysate. Adenosine concentration reached 12 mu mol L(-1) during the first preconditioning period while an attenuation was typical for the following three preconditioning periods. The sum of the concentrations oi adenosine. inosine and hypoxanthine was significantly lower during index ischaemia in the preconditioned groups displaying a peak value of 115 mu mol L(-1). The corresponding value for unpreconditioned hearts was 230 mu mol L(-1). The part of adenosine was 5% and less than 1%. respectively. Pyruvate concentration decreased during each brief ischaemic period of preconditioning rising to a higher level of reperfusion. Thedecrease in pyruvate was smaller in the controls during index ischaemia. The effects of beta-blockade and preconditioning on ischaemic metabolism were comparable and the results of the two treatments were not additive in this respect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:09:58