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Titolo:
D-2-DOPAMINE RECEPTOR TAQI-A ALLELES IN MEDICALLY ILL ALCOHOLIC AND NONALCOHOLIC PATIENTS
Autore:
NOBLE EP; SYNDULKO K; FITCH RJ; RITCHIE T; BOHLMAN MC; GUTH P; SHERIDAN PJ; MONTGOMERY A; HEINZMANN C; SPARKES RS; BLUM K;
Indirizzi:
UNIV CALIF LOS ANGELES,ALCOHOL RES CTR,INST NEUROPSYCHIAT LOS ANGELESCA 90024 UNIV CALIF LOS ANGELES,INST BRAIN RES LOS ANGELES CA 90024 DEPT VET AFFAIRS MED CTR,DEPT NEUROL LOS ANGELES CA 00000 DEPT VET AFFAIRS MED CTR,NEUROL SERV LOS ANGELES CA 00000 UNIV CALIF LOS ANGELES,DEPT MED LOS ANGELES CA 00000 UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL SAN ANTONIO TX 00000 UNIV TEXAS,HLTH SCI CTR,DIV ADDICT DIS,PHARMACOGENET LAB SAN ANTONIO TX 00000
Titolo Testata:
Alcohol and alcoholism
fascicolo: 6, volume: 29, anno: 1994,
pagine: 729 - 744
SICI:
0735-0414(1994)29:6<729:DRTAIM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING RATS; D2-DOPAMINE RECEPTOR; NUCLEUS-ACCUMBENS; D2 RECEPTOR; GENETIC PREDISPOSITION; SUBSTANCE-ABUSE; DRUG-ABUSE; ASSOCIATION; DEPENDENCE; RFLP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
69
Recensione:
Indirizzi per estratti:
Citazione:
E.P. Noble et al., "D-2-DOPAMINE RECEPTOR TAQI-A ALLELES IN MEDICALLY ILL ALCOHOLIC AND NONALCOHOLIC PATIENTS", Alcohol and alcoholism, 29(6), 1994, pp. 729-744

Abstract

The prevalence of TaqI A alleles of the D-2 dopamine receptor (DRD2) gene was examined in two subgroups of medically ill nonalcoholics (more prevalent and less prevalent substance users, MPSU and LPSU, respectively) and in two subgroups of medically ill alcoholics (more severe and less severe alcoholics, MSA and LSA, respectively). The prevalence of the A1 allele in the 80 nonalcoholic and 73 alcoholic patients was 30.0% and 52.1%, respectively (P = 0.009). In the four subgroups of these patients, the prevalence of this allele was: LPSU = 18.2%, MPSU = 34.5%, LSA = 44% and MSA = 58.3%. Linear trend analysis showed that asthe use of substances and severity of alcoholism increase, so does A1prevalence (P = 0.001). Specific, subgroup comparisons showed A1 prevalence in MSA to be about 3-fold (P = 0.007) and 1.5-fold (P = 0.04) higher than in LPSU and MPSU subgroups, respectively. Similarly, in a combined analysis of independent studies, A1 prevalence in MSA was higher when compared to LSA (P < 5 x 10(-3)), MPSU (P < 10(-4)) and LPSU (P < 10(-8)) subgroups. There was virtually no difference in the prevalence of the A1 allele between LSA and MPSU subgroups. None of the specific medical or neuropsychiatric complications of alcoholism was associated with the Al allele. In conclusion, the severity of alcohol dependence in alcoholics and of substance use behaviors in controls are important variables in DRD2 allelic association. The present report and converging lines of evidence suggest that the DRD2 locus could represent a prominent gene risk factor for susceptibility to severe alcoholism. However, other genes and environmental factors, when combined, stillplay the larger role.

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Documento generato il 16/07/20 alle ore 16:46:32