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Titolo:
GENETIC-POLYMORPHISM OF LIVER ALCOHOL-DEHYDROGENASE IN SPANISH SUBJECTS - SIGNIFICANCE OF ALCOHOL-CONSUMPTION AND LIVER-DISEASE
Autore:
PARES X; FARRES J; PARES A; SOLER X; PANES J; FERRE JL; CABALLERIA J; RODES J;
Indirizzi:
UNIV AUTONOMA BARCELONA,FAC SCI,DEPT BIOCHEM & MOLEC BIOL E-08193 BARCELONA SPAIN UNIV BARCELONA,HOSP CLIN & PROV,LIVER UNIT BARCELONA SPAIN
Titolo Testata:
Alcohol and alcoholism
fascicolo: 6, volume: 29, anno: 1994,
pagine: 701 - 705
SICI:
0735-0414(1994)29:6<701:GOLAIS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDEHYDE DEHYDROGENASES; METABOLIZING ENZYMES; CIRRHOSIS; PREDISPOSITION; GENOTYPES; JAPANESE; STOMACH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
X. Pares et al., "GENETIC-POLYMORPHISM OF LIVER ALCOHOL-DEHYDROGENASE IN SPANISH SUBJECTS - SIGNIFICANCE OF ALCOHOL-CONSUMPTION AND LIVER-DISEASE", Alcohol and alcoholism, 29(6), 1994, pp. 701-705

Abstract

Class I alcohol dehydrogenase (ADH) phenotypes have been studied by starch gel electrophoresis and activity analysis in liver tissue obtained at necropsy from 61 non-alcoholic subjects with normal liver (controls), and in biopsies from 60 chronic alcoholics with liver disease and from 24 subjects with non-alcoholic liver disease. Twenty-three per cent of controls exhibited the ADH(2)(2-1) phenotype, which representsthe highest frequency for atypical ADH found in a Caucasian population. Both alcoholic and non-alcoholic patients with liver disease showeda lower frequency of the atypical phenotype (6.6% and 8.8%, respectively). No differences in the ADH(2) locus were detected among groups ofpatients with different severity of alcoholic and non-alcoholic liverdisease. The allele frequencies of the ADH(3) locus for the controls (ADH(3)(I) = 0.63, ADH(3)(2) = 0.37) are common to those of other Caucasian populations. Similar ADH(3) allele frequencies were observed in patients with alcoholic and non-alcoholic liver disease. Discrepanciesbetween the various phenotyping and genotyping studies now known for several populations suggest that local differences may exist in the distribution of the ADH polymorphism in even geographically close regions, and that the effect of ADH polymorphism on vulnerability towards alcohol may not be identical in different populations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:42:23