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Titolo:
THIOL SUPPLIER N-ACETYLCYSTEINE ENHANCES CONJUGATE FORMATION BETWEEN NATURAL-KILLER-CELLS AND K562 OR U937 TARGETS BUT INCREASES THE LYTIC FUNCTION ONLY AGAINST THE LATTER
Autore:
MALORNI W; DAMBROSIO A; RAINALDI G; RIVABENE R; VIORA M;
Indirizzi:
IST SUPER SANITA,DEPT ULTRASTRUCT,VIALE REGINA ELENA 299 I-00161 ROMEITALY IST SUPER SANITA,DEPT IMMUNOL I-00161 ROME ITALY
Titolo Testata:
Immunology letters
fascicolo: 3, volume: 43, anno: 1994,
pagine: 209 - 214
SICI:
0165-2478(1994)43:3<209:TSNECF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIATED CYTOTOXICITY; ADHESION;
Keywords:
NK-CELL-MEDIATED CYTOTOXICITY; CYTOSKELETON; N-ACETYLCYSTEINE (NAC);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
W. Malorni et al., "THIOL SUPPLIER N-ACETYLCYSTEINE ENHANCES CONJUGATE FORMATION BETWEEN NATURAL-KILLER-CELLS AND K562 OR U937 TARGETS BUT INCREASES THE LYTIC FUNCTION ONLY AGAINST THE LATTER", Immunology letters, 43(3), 1994, pp. 209-214

Abstract

In this in vitro study, an evaluation of the importance of intracellular oxidative balance on cell-mediated cytotoxicity was performed by analyzing the effects of the antioxidant N-acetylcysteine (NAG), a specific thiol supplier, on natural killer (NK) cell-mediated cytotoxicity. The results obtained indicate that an enhancement of target cell (TC) killing can be detected when a pre-exposure of effector cells (EC) to NAC was performed. However, this effect seems to depend upon the TC type used. In fact, the increase of EC activity was detected against the differentiated U937 TC while no changes were detected by the same effecters against K562 cells. The mechanism of this enhancement seems to be ascribable to an increased ability of NAG-exposed NK cells to form conjugates (binding) which, in turn, appears to be due to a specificeffect of NAC on actin microfilaments. A role for NAC as a cytoskeleton thiol-modifier contributing to the activation of effector cells canthus be hypothesized.

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Documento generato il 04/04/20 alle ore 02:47:47