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Titolo:
REPEATED INTRADERMAL INJECTION OF LOW-DOSE CARRAGEENAN INDUCES TACHYPHYLAXIS TO EVOKED HYPERALGESIA
Autore:
WELSH EM; NOLAN AM;
Indirizzi:
UNIV GLASGOW,SCH VET,DEPT VET PHARMACOL,BEARSDEN RD GLASGOW G61 1QH LANARK SCOTLAND
Titolo Testata:
Pain
fascicolo: 3, volume: 59, anno: 1994,
pagine: 415 - 421
SICI:
0304-3959(1994)59:3<415:RIIOLC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT PAW; NEUROGENIC INFLAMMATION; SYNAPTIC TRANSMISSION; PAIN HYPERSENSITIVITY; FORMALIN TEST; HEAT INJURY; SENSITIZATION; POTENTIATION; SENSITIVITY; ANTAGONIST;
Keywords:
CARRAGEENAN; STIMULATION, NOXIOUS MECHANICAL; STIMULATION, NOXIOUS THERMAL; HYPERALGESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Welsh e A.M. Nolan, "REPEATED INTRADERMAL INJECTION OF LOW-DOSE CARRAGEENAN INDUCES TACHYPHYLAXIS TO EVOKED HYPERALGESIA", Pain, 59(3), 1994, pp. 415-421

Abstract

Changes in the thresholds to noxious mechanical and thermal stimulation were monitored in a group of normal sheep at different times (30 min-24 h) following intradermal injection of either low-dose (0.0625%) carrageenan, a widely used mucopolysaccharide irritant, or saline (0.9%) into the lateral aspect of the fore limb. Thresholds to noxious mechanical stimulation were measured on the ipsilateral limb whereas thresholds to noxious thermal stimulation were measured at a site distant to that of the injection, the ipsilateral ear. During the first 2 h after carrageenan injection the thresholds to noxious thermal stimulationfell, while thresholds to noxious mechanical stimulation were unaltered, The evoked hyperalgesia was reversed by the administration of non-steroidal anti-inflammatory agents. Hyperalgesia was not present 4 h after carrageenan injection in control or treated animals. This experiment was carried out on 3 further occasions and a diminishing response to injection of carrageenan was observed, suggesting development of tachyphylaxis to evoked thermal hyperalgesia.

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Documento generato il 09/04/20 alle ore 07:41:27