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Titolo:
GENETIC DETERMINATION OF TELOMERE SIZE IN HUMANS - A TWIN STUDY OF 3 AGE-GROUPS
Autore:
SLAGBOOM PE; DROOG S; BOOMSMA DI;
Indirizzi:
TNO PG,DEPT VASC & CONNECT TISSUE RES,ZERNIKEDREEF 9,POB 430 2300 AK LEIDEN NETHERLANDS FREE UNIV AMSTERDAM,DEPT PSYCHOL AMSTERDAM NETHERLANDS
Titolo Testata:
American journal of human genetics
fascicolo: 5, volume: 55, anno: 1994,
pagine: 876 - 882
SICI:
0002-9297(1994)55:5<876:GDOTSI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN FIBROBLASTS; PEDIGREE ANALYSIS; DNA; LYMPHOCYTES; CHROMOSOMES; ELONGATION; YEAST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
P.E. Slagboom et al., "GENETIC DETERMINATION OF TELOMERE SIZE IN HUMANS - A TWIN STUDY OF 3 AGE-GROUPS", American journal of human genetics, 55(5), 1994, pp. 876-882

Abstract

Reduction of telomere length has been postulated to be a causal factor in cellular aging. Human telomeres terminate in tandemly arranged repeat arrays consisting of the (TTAGGG) motif. The length of these arrays in cells from human mitotic tissues is inversely related to the ageof the donor, indicating telomere reduction with age. In addition to telomere length differences between different age cohorts, considerable variation is present among individuals of the same age. To investigate whether this variation can be ascribed to genetic influences, we have measured the size of terminal restriction fragments (TRFs) in HaeIII-digested genomic DNA from 123 human MZ and DZ twin pairs 2-95 years of age. The average rate of telomere shortening was 31 bp/year, which is similar to that observed by others. Statistical analysis in 115 pairs 2-63 years of age indicates a 78% heritability for mean TRF length in this age cohort. The individual differences in mean TRF length in blood, therefore, seem to a large extent to be genetically determined.

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Documento generato il 17/02/20 alle ore 17:21:28