Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EYE-MOVEMENTS IN MONKEYS WITH LOCAL DOPAMINE DEPLETION IN THE CAUDATE-NUCLEUS .2. DEFICITS IN VOLUNTARY SACCADES
Autore:
KORI A; MIYASHITA N; KATO M; HIKOSAKA O; USUI S; MATSUMURA M;
Indirizzi:
JUNTENDO UNIV,SCH MED,DEPT PHYSIOL,BUNKYO KU,2-1-1 HONGO TOKYO 113 JAPAN NATL INST PHYSIOL SCI,DEPT BIOL CONTROL SYST,NEURAL CONTROL LAB OKAZAKI AICHI 444 JAPAN
Titolo Testata:
The Journal of neuroscience
fascicolo: 1, volume: 15, anno: 1995,
parte:, 2
pagine: 928 - 941
SICI:
0270-6474(1995)15:1<928:EIMWLD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
NIGRA PARS RETICULATA; PARKINSONS-DISEASE; SUBSTANTIA-NIGRA; FUNCTIONAL-PROPERTIES; PREFRONTAL CORTEX; INTRACORTICAL MICROSTIMULATION; REACTION-TIMES; OWL MONKEYS; NEURONS; PRIMATE;
Keywords:
MONKEY; MPTP; VISUALLY GUIDED SACCADE; MEMORY-GUIDED SACCADE; CAUDATE NUCLEUS; DOPAMINE DEFICIENCY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
A. Kori et al., "EYE-MOVEMENTS IN MONKEYS WITH LOCAL DOPAMINE DEPLETION IN THE CAUDATE-NUCLEUS .2. DEFICITS IN VOLUNTARY SACCADES", The Journal of neuroscience, 15(1), 1995, pp. 928-941

Abstract

Unilateral infusion of MPTP into the monkey caudate nucleus produced deficits in task-specific saccades, in addition to the deficits in spontaneous eye movements (preceding article). We trained three monkeys to perform two kinds of saccade tasks: (1) saccade task for eliciting visually guided saccades and (2) delayed saccade task for eliciting memory-guided saccades. After the MPTP infusion, dopaminergic function, estimated by tyrosine hydroxylase (TH) immunoreactivity, was shown to be decreased locally around the infusion site at the head-body junctionof the caudate. We found that the deficits were prominent in the saccades directed to the side contralateral to the infusion (contralateralsaccades). Memory-guided saccades were sometimes misdirected to the ipsilateral side even when the cue stimulus was presented on the contralateral side. Among the parameters of saccades, a selective change wasfound in the saccade latency: the latency was prolonged consistently in contralateral memory-guided saccades. The amplitude and velocity ofsaccades decreased in contralateral saccades, either memory guided orvisually guided. The duration of saccades tended to increase in visually-guided saccades and memory-guided saccades, in both directions. Only one monkey, in which the decrease in TH activity included a large part of the putamen and the head of the caudate, showed prolongation ofmanual reaction time for lever release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 12:28:50