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Titolo:
AGED STONE MAZE-IMPAIRED RATS EXHIBIT REDUCED STRIATAL MUSCARINIC RECEPTOR DENSITIES
Autore:
BRATT AM; KELLY ME; DOMENEY AM; NAYLOR RJ; COSTALL B;
Indirizzi:
UNIV BRADFORD,SCH PHARM,RICHMOND RD BRADFORD BD7 1DP W YORKSHIRE ENGLAND MEMPHIS STATE UNIV,DEPT PSYCHOL MEMPHIS TN 38152
Titolo Testata:
NeuroReport
fascicolo: 18, volume: 5, anno: 1994,
pagine: 2678 - 2682
SICI:
0959-4965(1994)5:18<2678:ASMRER>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL GANGLIA; DEFICITS; BINDING; CORTEX;
Keywords:
AGED RATS; STONE MAZE; MUSCARINIC RECEPTOR BINDING; [H-3] QNB; STRIATUM; FRONTAL CORTEX; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Bratt et al., "AGED STONE MAZE-IMPAIRED RATS EXHIBIT REDUCED STRIATAL MUSCARINIC RECEPTOR DENSITIES", NeuroReport, 5(18), 1994, pp. 2678-2682

Abstract

MUSCARINIC receptor densities, measured by saturation radioligand binding using the muscarinic antagonist [H-3]QNB, were compared in the striatum, frontal cortex and hippocampus between two populations of young (3 month) and aged (12-20 month) Hooded Lister rats which had previously been tested in a complex maze task. Aged rats were impaired in their performance of a Stone (14-unit T-maze) task and were less spontaneously active than young rats. Muscarinic receptor numbers were significantly decreased in the striatum of aged rats, whilst numbers in the hippocampus and frontal cortex and receptor affinities in all three areas were unaltered. These results indicate that the age-associated depletion of striatal muscarinic receptors may contribute to deficits in cognitive processing and/or motor behaviour which underlie impairmentsin the performance of complex spatial tasks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:34:23