Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
STUDIES ON IN-VITRO METABOLISM OF 7-N,N-DIMETHYLAMINO-1,2,3,4,5-PENTATHIOCYCLOOCTANE BY RAT-LIVER MICROSOMES PRETREATED WITH PHENOBARBITAL
Autore:
XIA SJ; ZHAO SS; WANG XD; XUE QK; YAN H; ZHOU PQ; LIANG EP; ZHANG CX; XIA T;
Indirizzi:
TONGJI MED UNIV,DEPT ENVIRONM HLTH WUHAN 430030 PEOPLES R CHINA HUBEI PROV INST CHEM,DIV MASS SPECTRA WUHAN 430074 PEOPLES R CHINA WUHAN WATER SUPPLY CO,DIV WATER QUAL WUHAN 430031 PEOPLES R CHINA
Titolo Testata:
Pesticide biochemistry and physiology
fascicolo: 1, volume: 51, anno: 1995,
pagine: 48 - 56
SICI:
0048-3575(1995)51:1<48:SOIMO7>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Xia et al., "STUDIES ON IN-VITRO METABOLISM OF 7-N,N-DIMETHYLAMINO-1,2,3,4,5-PENTATHIOCYCLOOCTANE BY RAT-LIVER MICROSOMES PRETREATED WITH PHENOBARBITAL", Pesticide biochemistry and physiology, 51(1), 1995, pp. 48-56

Abstract

Polythiocycloalkane (PTCA), -N,N-dimethylamino-1,2,3,4,5-pentathiocyclooctane, is an insecticide developed in China during the past 10 years. In vitro metabolism of PTCA by rat liver microsomes was studied. The metabolites were isolated and characterized by high-performance liquid chromatography, gas chromatography-mass spectroscopy, and infrared spectroscopy. The results were verified by comparison with synthesizedstandards, evisect (N,N-dimethyl-1,2,3-trithian-5-amine) and nereistoxin (N,N-dimethyl-1,2-dithiolan-4-amine), or by biochemical analysis. The main metabolites were evisect, nereistoxin, monomethyl nereistoxin, 2-methylaminopropane, and sulfur polymers. The process was catalyzedmainly by enzymatic reactions, such as desulfuration and demethylation. The in vitro metabolism of PTCA by rat liver microsomes pretreated with phenobarbital may be a detoxification process. (C) 1995 Academic Press, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:43:01