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Titolo:
THE LATERAL GANGLIONIC EMINENCE IS THE ORIGIN OF CELLS COMMITTED TO STRIATAL PHENOTYPES - NEURAL TRANSPLANTATION AND DEVELOPMENTAL EVIDENCE
Autore:
DEACON TW; PAKZABAN P; ISACSON O;
Indirizzi:
MCLEAN HOSP,MRC 119,NEUROREGENERAT LAB,115 MILL ST BELMONT MA 02178 HARVARD UNIV,SCH MED,PROGRAM NEUROSCI BOSTON MA 02115 MASSACHUSETTS GEN HOSP,DEPT NEUROL BOSTON MA 02115 MASSACHUSETTS GEN HOSP,DEPT NEUROSURG BOSTON MA 02115 BOSTON UNIV BOSTON MA 02115
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 668, anno: 1994,
pagine: 211 - 219
SICI:
0006-8993(1994)668:1-2<211:TLGEIT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-LESIONED STRIATUM; RAT NEOSTRIATAL GRAFTS; ELECTRON-MICROSCOPIC ANALYSIS; HOST DOPAMINERGIC AFFERENTS; INTRASTRIATAL GRAFTS; EFFERENT PROJECTIONS; HUNTINGTONS-DISEASE; PRIMARY CULTURE; MESSENGER-RNA; TISSUE GRAFTS;
Keywords:
STRIATAL GRAFT; ALLOGRAFT; CELL FATE; HUNTINGTONS DISEASE; NEURONAL REGENERATION; DARPP-32; CALBINDIN; ACETYLCHOLINESTERASE; TYROSINE HYDROXYLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
T.W. Deacon et al., "THE LATERAL GANGLIONIC EMINENCE IS THE ORIGIN OF CELLS COMMITTED TO STRIATAL PHENOTYPES - NEURAL TRANSPLANTATION AND DEVELOPMENTAL EVIDENCE", Brain research, 668(1-2), 1994, pp. 211-219

Abstract

In order to determine whether the lateral ganglionic eminence (LGE) of the fetal telencephalon is the primary source of striatal precursorsin striatal transplants and tissue cultures, cells derived exclusively from the LGE of fetal rat brains were transplanted into the quinolinic-acid-lesioned striatum of adult rats. After 2-3 months they produced grafts that were almost entirely AChE-positive as well as DARPP-32-,TH-, and calbindin-immunoreactive. The grafts were integrated into the host striatum so that host corticofugal fiber tracts interdigitated with graft tissues similar to the way they penetrate the gray matter of the normal striatum. Fast Blue dye injected into the ipsilateral globus pallidus of LGE grafted produced retrogradely labeled neurons within the grafts, but Fluorogold dye injected into the ipsilateral substantia nigra did not. In a separate experiment using DARPP-32-immunohistochemstry as a striatal marker, fetal (E16) and neonatal (P2) rat brains showed DARPP-32 immunoreactivity in the LGE but not in the adjacentmedial ganglionic eminence (MGE). In summary, both fetal LGE cells and LGE grafts express specific striatal markers, and LGE grafts integrate into the host striatum and innervate the major striatal efferent target within the host brain. These data suggest that the LGE is the origin of cells committed to striatal phenotypes in the developing brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 03:15:24