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Titolo:
ATRIAL-NATRIURETIC-PEPTIDE - RELATION TO LEFT-VENTRICULAR FILLING PROPERTIES IN PATIENTS WITH SYSTEMIC-SCLEROSIS
Autore:
KAZZAM E; CAIDAHL K; HEDNER T; HEDNER J; WALDENSTROM A;
Indirizzi:
UNIV UPPSALA HOSP,DEPT INTERNAL MED S-75185 UPPSALA SWEDEN SAHLGRENS UNIV HOSP,DEPT CLIN PHYSIOL S-41345 GOTHENBURG SWEDEN SAHLGRENS UNIV HOSP,DEPT CLIN PHARMACOL S-41345 GOTHENBURG SWEDEN UMEA UNIV HOSP,DEPT INTERNAL MED S-90185 UMEA SWEDEN
Titolo Testata:
International journal of cardiology
fascicolo: 2, volume: 47, anno: 1994,
pagine: 151 - 156
SICI:
0167-5273(1994)47:2<151:A-RTLF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEART-FAILURE; DILATED CARDIOMYOPATHY; PLASMA-LEVELS; SECRETION; PRESSURE; INFUSION; RAT;
Keywords:
ATRIAL NATRIURETIC PEPTIDE; DIASTOLIC FUNCTION; ECHOCARDIOGRAPHY; LEFT VENTRICLE; MITRAL REGURGITATION; SYSTEMIC SCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
E. Kazzam et al., "ATRIAL-NATRIURETIC-PEPTIDE - RELATION TO LEFT-VENTRICULAR FILLING PROPERTIES IN PATIENTS WITH SYSTEMIC-SCLEROSIS", International journal of cardiology, 47(2), 1994, pp. 151-156

Abstract

To determine the relation between left ventricular filling propertiesand plasma atrial natriuretic peptide in systemic sclerosis, we evaluated 30 consecutive patients and 48 age- and sex-matched controls. Thevenous plasma atrial natriuretic peptide was measured by radio-immunoassay. Left ventricular involvement was evaluated by echocardiography and mitral regurgitation was evaluated by Doppler. The patient group had markedly elevated plasma atrial natriuretic peptide as compared to the matched controls (239.4 +/- 59 vs. 178.2 +/- 36 pmol/l, P < 0.0005). We found signs of impaired left ventricular filling properties among the patients, with an increase of the Doppler A-wave velocity and A/E ratio. A relative reduction of early filling was found in spite of some degree of mitral regurgitation in two-thirds of the patients. The plasma atrial natriuretic peptide concentration was related to the A-wave velocity (r = 0.44, P < 0.0005), the A/E ratio (r = 0.40, P < 0.005), and also to the degree of mitral regurgitation (r = 0.43, P < 0.005). The relationship to the A-wave velocity remained when considering possible confounding factors. We conclude that the previously observedfibrotic process in systemic sclerosis does not prevent production and liberation of plasma atrial natriuretic peptide in relation to factors distending the left atrium, such as altered left ventricular filling propeties and the presence of mitral regurgitation. However, the moderate relationships between atrial natriuretic peptide and haemodynamic variables indicate that the peptide might also be an independent indicator of cardiac involvement in systemic sclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 19:30:18