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Titolo:
A POSITRON EMISSION TOMOGRAPHIC STUDY OF SIMPLE PHOBIC SYMPTOM PROVOCATION
Autore:
RAUCH SL; SAVAGE CR; ALPERT NM; MIGUEL EC; BAER L; BREITER HC; FISCHMAN AJ; MANZO PA; MORETTI C; JENIKE MA;
Indirizzi:
MASSACHUSETTS GEN HOSP E,149 13TH ST BOSTON MA 02129 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT PSYCHIAT BOSTON MA 00000 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT RADIOL BOSTON MA 00000 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DIV NUCL MED,POSITRON EMISS TOMOG LAB BOSTON MA 00000
Titolo Testata:
Archives of general psychiatry
fascicolo: 1, volume: 52, anno: 1995,
pagine: 20 - 28
SICI:
0003-990X(1995)52:1<20:APETSO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSESSIVE-COMPULSIVE DISORDER; CEREBRAL BLOOD-FLOW; GLUCOSE-METABOLISM; PANIC DISORDER; ANXIETY; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Rauch et al., "A POSITRON EMISSION TOMOGRAPHIC STUDY OF SIMPLE PHOBIC SYMPTOM PROVOCATION", Archives of general psychiatry, 52(1), 1995, pp. 20-28

Abstract

Background: The goal of this study was to determine the mediating neuroanatomy of simple phobic symptoms. Methods: Positron emission tomography and oxygen 15 were used to measure normalized regional cerebral blood flow in seven subjects with simple phobia during control and provoked states. Stereotactic transformation and statistical parametric mapping techniques were employed to determine the locations of significant activation. Results: Statistical parametric maps demonstrated significant increases in normalized regional blood flow for the symptomaticstate compared with the control state in the anterior cingulate cortex, the insular cortex, the anterior temporal cortex, the somatosensorycortex, the posterior medial orbitofrontal cortex, and the thalamus. Conclusions: The results suggest that anxiety associated with the simple phobic symptomatic state is mediated by paralimbic structures. Moreover, activation of somatosensory cortex may reflect tactile imagery as one component of the phobic symptomatic condition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 17:07:24