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Titolo:
STRIKING INVERSE CORRELATION BETWEEN IGG ANTI-F(AB')(2) AND AUTOANTIBODY PRODUCTION IN PATIENTS WITH COLD AGGLUTINATION
Autore:
TERNESS P; KIRSCHFINK M; NAVOLAN D; DUFTER C; KOHL I; OPELZ G; ROELCKE D;
Indirizzi:
UNIV HEIDELBERG,INST IMMUNOL,INF 305 D-69120 HEIDELBERG GERMANY UNIV MED & PHARM,DEPT PHYSIOL TIMISOARA ROMANIA
Titolo Testata:
Blood
fascicolo: 2, volume: 85, anno: 1995,
pagine: 548 - 551
SICI:
0006-4971(1995)85:2<548:SICBIA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FC-GAMMA RECEPTORS; LYMPHOCYTES-B; CROSS-LINKING; BLOOD-CELLS; ANTIBODIES; ASSOCIATION; SUPPRESSION; ANTIGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
P. Terness et al., "STRIKING INVERSE CORRELATION BETWEEN IGG ANTI-F(AB')(2) AND AUTOANTIBODY PRODUCTION IN PATIENTS WITH COLD AGGLUTINATION", Blood, 85(2), 1995, pp. 548-551

Abstract

Previous experiments showed that the physiologic IgG anti-F(ab')(2) antibody suppresses the response of human autoreactive B cells. In the present study, we analyzed the IgG anti F(ab')(2) antibody in 293 patients with cold agglutination (CA). Their average IgG anti-F(ab')(2) titer was not much different (211 +/- 8.3) from that of 279 healthy persons (195 +/- 6.7). However, CA patients with high anti-F(ab')(2) titers had low CA autoantibody titers and vice versa (P = .0028; rho = -0.175). The stratification of patients according to the auto-antibody's specificity (anti-l, anti-i, anti-Pr) showed an inverse correlation between anti-F(ab')(2) and CA in the anti-l group (P = .0057; rho = -0.180). Interestingly, the association was present only in patients whose disease was caused by noninfectious agents (P < .0001; rho = -0.423). The inverse correlation argues for an important role of the IgG anti-F(ab')(2) in the regulation of autoantibody production in CA patients. (C) 1995 by The American Society of Hematology.

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Documento generato il 05/12/20 alle ore 13:12:48