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Titolo:
PLATELET-ACTIVATING-FACTOR RECEPTOR ANTAGONIST IMPROVES RENAL-FUNCTION AND GLOMERULAR-LESIONS IN RENAL ABLATION
Autore:
THAISS F; MIHATSCH MJ; OBERLE G; HABERSTROH U; BRECHT HM; STAHL RAK;
Indirizzi:
UNIV HAMBURG HOSP,DEPT INTERNAL MED,DIV NEPHROL,MARTINISTR 52 D-20246HAMBURG GERMANY UNIV HAMBURG HOSP,DEPT MED,DIV NEPHROL HAMBURG GERMANY UNIV BASEL,DEPT PATHOL BASEL SWITZERLAND
Titolo Testata:
The Journal of laboratory and clinical medicine
fascicolo: 6, volume: 124, anno: 1994,
pagine: 775 - 781
SICI:
0022-2143(1994)124:6<775:PRAIR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESANGIAL CELL CONTRACTION; DIETARY-PROTEIN INTAKE; THROMBOXANE SYNTHESIS; REMNANT KIDNEY; RATS; DISEASE; INJURY; MODEL; PAF; PROSTAGLANDIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
F. Thaiss et al., "PLATELET-ACTIVATING-FACTOR RECEPTOR ANTAGONIST IMPROVES RENAL-FUNCTION AND GLOMERULAR-LESIONS IN RENAL ABLATION", The Journal of laboratory and clinical medicine, 124(6), 1994, pp. 775-781

Abstract

In the renal ablation model hemodynamic changes, glomerular hypertrophy, and the release of inflammatory mediators contribute to structuraldamage and functional changes. Platelet-activating factor (PAF) has both hemodynamic and immune-mediating properties. We therefore examinedthe role for a PAF receptor antagonist (WEB 2170) on glomerular hemodynamic function, albuminuria, and structural alterations in a rat model of renal ablation (Nx). WEB 2170 treatment was started 10 weeks after renal ablation, and the variables were assessed at 36 weeks after surgery. WEB 2170 significantly improved inulin and PAH clearances at 36weeks (inulin clearance: Nx, 182 +/- 28 mu l/min/100 gm body weight; Nx plus WEB, 284 +/- 19 mu l/min/100 gm body weight; p < 0.05; PAH clearance: Nx, 718 +/- 85 mu l/min/100 gm body weight; Nx plus WEB, 1215 /- 103 mu l/min/100 gm body weight; p < 0.05). Glomerular prostaglandin E(2) (PGE(2)) formation was significantly increased in nephrectomized rats treated with WEB 2170 when compared with nephrectomized animals not treated (PGE,: Nx, 103 +/- 16 pg/min/mg protein; Nx plus WEB, 182 +/- 19 pg/min/mg protein; p < 0.01). The PAF receptor antagonist didnot change albuminuria (Nx, 205 +/- 56 mg/24 hr; Nx plus WEB, 178 +/-48 mg/24 hr). Glomeruli of rats treated with WEB 2170 had significantly fewer sclerotic lesions at 36 weeks when compared with untreated animals (Nx, 36.5 +/- 4.4%; Nx plus WEB, 19.3% +/- 3.7%; p < 0.05). The results demonstrate that a PAF receptor antagonist significantly improves whole kidney clearances and glomerular morphology. PAF might therefore be an important mediator in the regulation of renal function and could be involved in the development of sclerosis in this model of chronic renal disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:04:39