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Titolo:
COMPARISON OF 2 BOVINE SURFACTANT PREPARA TIONS IN THE TREATMENT OF RESPIRATORY-DISTRESS-SYNDROME IN PREMATURES
Autore:
SCHARF J; KLINGE J; BOSWALD M; DISTEL D; WILD F; TENBRINK U; HARMS D;
Indirizzi:
UNIV ERLANGEN NURNBERG,KINDER & JUGEND KLIN,LOSCHGESTR 15 D-91094 ERLANGEN GERMANY
Titolo Testata:
Monatsschrift fur Kinderheilkunde
fascicolo: 12, volume: 142, anno: 1994,
pagine: 961 - 966
SICI:
0026-9298(1994)142:12<961:CO2BSP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
GER
Keywords:
RESPIRATORY DISTRESS SYNDROME; BOVINE SURFACTANT; EFFICACY; PREMATURE INFANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
J. Scharf et al., "COMPARISON OF 2 BOVINE SURFACTANT PREPARA TIONS IN THE TREATMENT OF RESPIRATORY-DISTRESS-SYNDROME IN PREMATURES", Monatsschrift fur Kinderheilkunde, 142(12), 1994, pp. 961-966

Abstract

Object: To compare the efficacy of two commercially available bovine surfactant preparations. Methods: Between february 1990 and september 1993 we treated 134 premature newborns with respiratory distress syndrome with one of the two bovine surfactant preparations (Alveofact, Fa. Thomae; Survanta, Fa. Abbott). Among these patients we were able to identify 38 pairs of patients from both groups with similar gestationalage, birth weight, and radiological degree of respiratory distress syndrome. The records of these patients were analyzed retrospectively with regard to mortality and morbidity and to the response to the surfactant substitution. Time of the first surfactant dose was similar in both groups. Results: There was no difference between the groups in mortality, the incidence of neonatal morbidity and in the duration of assisted ventilation or supplemental oxygen administration. Six patients showed no or poor response to surfactant treatment. During the first hours after the first surfactant dose the average FiO(2) was significantly lower in the Alveofact group. But during the following hours 50% ofthe Alveofact treated infants showed a relapse and were treated againwhereas only 13.3% of Survanta treated infants needed a second dose. The average amount of surfactant was 114.2 +/- 36.7 mg/kg body weight in the Survanta treated group and 229.3 +/- 154.4 mg/kg body weight inthe Alveofact treated group. Conclusion: We found no difference between the two groups with regard to the incidence of death or neonatal morbidities, although there was a significant difference in the initial response to treatment and in the number and dose of surfactant substitutions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:36:50