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Titolo:
CLONING, SEQUENCE-ANALYSIS AND EXPRESSION PATTERN OF MOUSE DESMOCOLLIN-2 (DSCP), A CADHERIN-LIKE ADHESION MOLECULE
Autore:
LORIMER JE; HALL LS; CLARKE JP; COLLINS JE; FLEMING TP; GARROD DR;
Indirizzi:
UNIV MANCHESTER,SCH BIOL SCI,CANC RES CAMPAIGN EPITHELIAL MORPHOGENESIS RES GR,STOPFORD BLDG MANCHESTER M13 9PT LANCS ENGLAND UNIV SOUTHAMPTON,DEPT BIOL SOUTHAMPTON S09 3TU HANTS ENGLAND
Titolo Testata:
Molecular membrane biology
fascicolo: 4, volume: 11, anno: 1994,
pagine: 229 - 236
SICI:
0968-7688(1994)11:4<229:CSAEPO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION; DESMOSOMAL CADHERINS; GLYCOPROTEIN-3 DESMOCOLLINS; CYTOPLASMIC DOMAINS; PEMPHIGUS-VULGARIS; DESMOGLEIN DGI; BETA-CATENIN; CALCIUM; FAMILY; IDENTIFICATION;
Keywords:
DESMOCOLLINS; DESMOSOMES; CADHERINS; CELL ADHESION; INTERCELLULAR JUNCTIONS; MOUSE EPITHELIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J.E. Lorimer et al., "CLONING, SEQUENCE-ANALYSIS AND EXPRESSION PATTERN OF MOUSE DESMOCOLLIN-2 (DSCP), A CADHERIN-LIKE ADHESION MOLECULE", Molecular membrane biology, 11(4), 1994, pp. 229-236

Abstract

Desmocollins are cadherin-like adhesion molecules of desmosomes. We have determined the full cDNA sequence of a murine desmocollin, the homologue of human and bovine type 2 desmocollins (DSC2), and studied itstissue distribution and expression in stratified epithelia. An 8.5 day mouse embryo cDNA library was screened yielding overlapping clones which encoded the mouse DSC2. This gene has an open reading frame of 2710 base pairs (bp) encoding a polypeptide of 902 amino acids (aa). Thepolypeptide comprises a signal peptide, a precursor peptide, and a mature protein of 766 aa having an extracellular domain of 549 aa, a single transmembrane domain and a cytoplasmic domain of 184 aa. Like other desmocollins, murine DSC2 has two products, Dsc2a and Dsc2b, produced by alternative splicing of a 46 bp exon which encodes 11 COOH-terminal aa followed by an in-frame stop codon. Inclusion of this exon formsDsc2b which is 54 aa shorter than Dsc2a. Mouse Dsc2a shows 75.7% amino acid identity to human and 63.3% identity to bovine Dsc2a. The mousedesmocollin is also homologous to the cadherins; 32.2% to the most closely related typical cadherin, human N-cadherin. DSC2 is ubiquitouslyexpressed in epithelial tissues and the heart of adult mice and from the blastocyst stage of development. In situ hybridization shows that the gene is most strongly expressed suprabasally in stratified epithelia, similar to the expression of bovine DSC2.

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Documento generato il 24/11/20 alle ore 22:08:09