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Titolo:
STUDY ON EFFICIENT SYNTHETIC ROUTES FOR 7-FLUOROPROSTAGLANDIN F2-ALPHA AND 7-FLUORO-17,20-DIMETHYL-2,4-METHYLENEPROSTACYCLIN
Autore:
MATSUMURA Y; SHIMADA T; WANG SZ; ASAI T; MORIZAWA Y; YASUDA A;
Indirizzi:
ASAHI GLASS CO LTD,RES CTR,KANAGAWA KU,1150 HAZAWA CHO YOKOHAMA KANAGAWA 221 JAPAN
Titolo Testata:
Bulletin of the Chemical Society of Japan
fascicolo: 12, volume: 69, anno: 1996,
pagine: 3523 - 3531
SICI:
0009-2673(1996)69:12<3523:SOESRF>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
STABLE PROSTACYCLIN ANALOGS; FLUOROPROSTACYCLIN ANALOGS; ANTIANGINAL AGENTS; HIGHLY POTENT; PROSTAGLANDIN; DERIVATIVES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
Y. Matsumura et al., "STUDY ON EFFICIENT SYNTHETIC ROUTES FOR 7-FLUOROPROSTAGLANDIN F2-ALPHA AND 7-FLUORO-17,20-DIMETHYL-2,4-METHYLENEPROSTACYCLIN", Bulletin of the Chemical Society of Japan, 69(12), 1996, pp. 3523-3531

Abstract

New and facile syntheses of 7-fluoroprostaglandin F-2a 1 and chemically stable 7-fluoro-17,20-dimethyl-2,4-methyleneprostacyclin 2 from commercially available methylenecyclopentanone are described. Construction of the key 7-hydroxyprostaglandin skeleton has been efficiently accomplished by the coupling of acetylenic acids with cyclopentane-carbaldehyde 4 under mild conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:20:38