Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COMPLETE DNA-SEQUENCE OF YEAST CHROMOSOME-II
Autore:
FELDMANN H; AIGLE M; ALJINOVIC G; ANDRE B; BACLET MC; BARTHE C; BAUR A; BECAM AM; BITEAU N; BOLES E; BRANDT T; BRENDEL M; BRUCKNER M; BUSSEREAU F; CHRISTIANSEN C; CONTRERAS R; CROUZET M; CZIEPLUCH C; DEMOLIS N; DELAVEAU T; DOIGNON F; DOMDEY H; DUSTERHUS S; DUBOIS E; DUJON B; ELBAKKOURY M; ENTIAN KD; FEUERMANN M; FIERS W; FOBO GM; FRITZ C; GASSENHUBER H; GLANSDORFF N; GOFFEAU A; GRIVELL LA; DEHAAN M; HEIN C; HERBERT CJ; HOLLENBERG CP; HOLMSTROM K; JACQ C; JACQUET M; JAUNIAUX JC; JONNIAUX JL; KALLESOE T; KIESAU P; KIRCHRATH L; KOTTER P; KOROLL S; LIEBL S; LOGGHE M; LOHAN AJE; LOUIS EJ; LI ZY; MAAT MJ; MALLET L; MANNHAUPT G; MESSENGUY F; MIOSGA T; MOLEMANS F; MULLER S; NASR F; OBERMAIER B; PEREA J; PIERARD A; PIRAVANDI E; POHL FM; POHL TM; POTIER S; PROFT M; PURNELLE B; RAD MR; RIEGER M; ROSE M; SCHAAFFGERSTENSCHLAGER I; SCHERENS B; SCHWARZLOSE C; SKALA J; SLONIMSKI PP; SMITS PHM; SOUCIET JL; STEENSMA HY; STUCKA R; URRESTARAZU A; VANDERAART QJM; VANDYCK L; VASSAROTTI A; VETTER I; VIERENDEELS F; VISSERS S; WAGNER G; DEWERGIFOSSE P; WOLFE KH; ZAGULSKI M; ZIMMERMANN FK; MEWES HW; KLEINE K;
Indirizzi:
UNIV MUNICH,INST PHYSIOL CHEM PHYS BIOCHEM & ZELLBIOL,SCHILLERSTR 44 D-80336 MUNICH GERMANY UNIV BORDEAUX 2,BIOL MOLEC & SEQUENCAGE LAB F-33076 BORDEAUX FRANCE GESELL ANAL TECHN & CONSULTING D-78467 CONSTANCE GERMANY FREE UNIV BRUSSELS,PHYSIOL CELLULAIRE & GENET LEVURES B-1050 BRUSSELSBELGIUM TH DARMSTADT,INST MIKROBIOL D-64287 DARMSTADT GERMANY CNRS,CTR GENET MOLEC F-91198 GIF SUR YVETTE FRANCE BIOTECHNOL INST,AGROIND TECHNOL & MOLEC BIOTECHNOL,FOOD TECHNOL RES INST DK-2800 LYNGBY DENMARK UNIV FRANKFURT,INST MIKROBIOL D-60596 FRANKFURT GERMANY GENOTYPE GMBH,BIOTECHNOL & MOLEK BIOL FORSCH D-69295 WILHELMSFELD GERMANY UNIV PARIS 11,INST GENET MICROBIOL,INFORMAT GENET & DEV,CNRS,URA 1354F-91405 ORSAY FRANCE STATE UNIV GHENT,MOLEC BIOL LAB B-9000 GHENT BELGIUM DEUTSCH KREBSFORSCHUNGSZENTRUM,INSERM,U375 D-69009 HEIDELBERG GERMANY ECOLE NORMALE SUPER,MOLEC GENET LAB,CNRS,URA 1302 F-75230 PARIS 05 FRANCE UNIV MUNICH,GENZENTRUM,MOLEK BIOL LAB D-82152 MARTINSRIED GERMANY UNIV FRANKFURT,BIOZENTRUM,INST MIKROBIOL D-60439 FRANKFURT GERMANY FREE UNIV BRUSSELS,INST RECH CERIA,COOVI,MICROBIOL LAB B-1070 BRUSSELS BELGIUM FREE UNIV BRUSSELS,ERFELKHEIDESLEER MICROBIOL LAB B-1070 BRUSSELS BELGIUM INST PASTEUR,DEPT BIOL MOLEC,UNITE GENET MOLEC LEVURES,CNRS,URA 1149 F-75724 PARIS 15 FRANCE UNIV STRASBOURG 1,CNRS,INST BOT F-67083 STRASBOURG FRANCE MAX PLANCK INST BIOCHEM,MIPS D-82152 MARTINSRIED GERMANY UNIV DUSSELDORF,INST MIKROBIOL D-40225 DUSSELDORF GERMANY UNIV CATHOLIQUE LOUVAIN,UNITE BIOCHIM PHYSIOL B-1348 LOUVAIN BELGIUM COMMISS EUROPEAN COMMUNITIES B-1049 BRUSSELS BELGIUM UNIV AMSTERDAM,MOLEC BIOL SECT,VAKGRP MOLEC CELBIOL 1098 SM AMSTERDAMNETHERLANDS UNIV DUBLIN TRINITY COLL,DEPT GENET DUBLIN 2 IRELAND JOHN RADCLIFFE HOSP,INST MOLEC MED OXFORD OX3 9DU ENGLAND UNIV KONSTANZ,FAK BIOL D-78434 CONSTANCE GERMANY LEIDEN UNIV,DEPT CELL BIOL & GENET,CLUSIUS LAB 2333 AL LEIDEN NETHERLANDS
Titolo Testata:
EMBO journal
fascicolo: 24, volume: 13, anno: 1994,
pagine: 5795 - 5809
SICI:
0261-4189(1994)13:24<5795:CDOYC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
OPEN READING FRAMES; TRANSFER-RNA GENES; MEMBRANE-SPANNING PROTEINS; SACCHAROMYCES-CEREVISIAE; KB SEGMENT; RIGHT ARM; TRANSPOSABLE ELEMENTS; MULTIPROTEIN COMPLEX; REPLICATION ORIGINS; GENOME;
Keywords:
COMPOSITIONAL BIAS; GENE FUNCTION; GENE REDUNDANCY; GENOME ORGANIZATION; PUTATIVE REPLICATION ORIGINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
83
Recensione:
Indirizzi per estratti:
Citazione:
H. Feldmann et al., "COMPLETE DNA-SEQUENCE OF YEAST CHROMOSOME-II", EMBO journal, 13(24), 1994, pp. 5795-5809

Abstract

In the framework of the EU genome-sequencing programmes, the completeDNA sequence of the yeast Saccharomyces cerevisiae chromosome II (807188 bp) has been determined. At present, this is the largest eukaryotic chromosome entirely sequenced. A total of 410 open reading frames (ORFs) were identified, covering 72% of the sequence. Similarity searches revealed that 124 ORFs (30%) correspond to genes of known function,51 ORFs (12.5%) appear to be homologues of genes whose functions are known, 52 others (12.5 %) have homologues the functions of which are not well defined and another 33 of the novel putative genes (8%) exhibit a degree of similarity which is insufficient to confidently assign function. Of the genes on chromosome II, 37-45% are thus of unpredictedfunction. Among the novel putative genes, we found several that are related to genes that perform differentiated functions in multicellularorganisms or are involved in malignancy. In addition to a compact arrangement of potential protein coding sequences, the analysis of this chromosome confirmed general chromosome patterns but also revealed particular novel features of chromosomal organization, Alternating regional variations in average base composition correlate with variations in local gene density along chromosome II, as observed in chromosomes XI and III. We propose that functional ARS elements are preferably located in the AT-rich regions that have a spacing of similar to-110 kb, Similarly, the 13 tRNA genes and the three Ty elements of chromosome II are found in AT-rich regions, In chromosome II, the distribution of coding sequences between the two strands is biased, with a ratio of 1.3:1, An interesting aspect regarding the evolution of the eukaryotic genome is the finding that chromosome II has a high degree of internal genetic redundancy, amounting to 16% of the coding capacity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:13:37