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Titolo:
WHOOPING-COUGH AND PARKINSONS-DISEASE
Autore:
DEPEDROCUESTA J; GUDMUNDSSON G; ABRAIRA V; GUDMUNDSSON G; LOVE A; TULINIUS H; VEIGA J; ALMAZAN J; PETERSEN IJ;
Indirizzi:
INST SALUD CARLOS III,CTR NACL EPIDEMIOL,DEPT EPIDEMIOL APLICADA,C SINESIO DELGADO 6 MADRID 28029 SPAIN KAROLINSKA INST,HUDDINGE UNIV HOSP,DEPT CLIN NEUROSCI & FAMILY MED,DIV NEUROL HUDDINGE SWEDEN NATL UNIV HOSP REYKJAVIK,DEPT NEUROL REYKJAVIK ICELAND HOSP RAMON Y CAJAL,BIOSTAT UNIT E-28034 MADRID SPAIN CARLOS III INST HLTH,REUNI CTR MADRID SPAIN NATL UNIV REYKJAVIK,DEPT MICROBIOL REYKJAVIK ICELAND NATL UNIV REYKJAVIK,DEPT SOCIAL MED REYKJAVIK ICELAND MINIST HLTH,DIV PHARMACEUT REYKJAVIK ICELAND
Titolo Testata:
International journal of epidemiology
fascicolo: 6, volume: 25, anno: 1996,
pagine: 1301 - 1311
SICI:
0300-5771(1996)25:6<1301:WAP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENVIRONMENTAL RISK-FACTORS; HYDROXYLASE GENE POLYMORPHISM; PERTUSSIS TOXIN; LEVODOPA USE; DOPAMINERGIC-NEURONS; CIGARETTE-SMOKING; ADENYLATE-CYCLASE; LEWY-BODY; L-DOPA; TIME;
Keywords:
DOPAMINE; DRUG USE; EPIDEMIOLOGY; ETIOLOGY; PARKINSONS DISEASE; PERTUSSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
61
Recensione:
Indirizzi per estratti:
Citazione:
J. Depedrocuesta et al., "WHOOPING-COUGH AND PARKINSONS-DISEASE", International journal of epidemiology, 25(6), 1996, pp. 1301-1311

Abstract

Background. We reported high levodopa use and prevalences of Parkinson's Disease (PD) in periodically, time-clustered, Icelandic cohorts born after major whooping cough epidemics (MWCE). Methods. In order to quantify a possible relationship between age at first post-birth MWCE and risk of PD we: 1) calculated cumulative incidences of PD during theperiod 1954-1963 in one-year Icelandic cohorts born between 1869 and 1927, using raw material from a reported survey; 2) identified MWCE from 1869 onwards in Iceland; 3) estimated cohort ages at onset of incidence period and at first MWCE; and 4) combined the above-mentioned information using log-linear models. In addition, we studied the prevalence of levodopa users in Icelandic birth cohorts during a recent period. Results. The curves of the above-mentioned incidences and prevalences in one-year birth-cohorts showed: 1) a similar, age-related, inverted V profile; and 2) a systematic notchy pattern, with peak values for one or both measurements for cohorts born during or after each of nineMWCE identified during the period 1869-1927. When 13 cohorts born in years with MWCE were excluded from the analysis, the risk of PD rose with age at first defined MWCE, with the linear increase being 8.4% peryear (95% CI:-0.1-18.3%). Conclusions. These results are consistent with reported effects of age at exposure in animal models of toxic parkinsonism, age-related changes in the dopamine receptor-GPT-binding protein-adenylatecyclase system observed in rats treated with pertussis toxin, and some PD epidemiological features. They suggest that pertussis neurotoxicity could be causally related to PD worldwide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 15:59:14