Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACUTE ANTAGONISM OF DOPAMINE D-2-LIKE RECEPTORS BY AMISULPRIDE - EFFECTS ON HORMONE-SECRETION IN HEALTHY-VOLUNTEERS
Autore:
WETZEL H; WIESNER J; HIEMKE C; BENKERT O;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55131 MAINZ GERMANY
Titolo Testata:
Journal of Psychiatric Research
fascicolo: 5, volume: 28, anno: 1994,
pagine: 461 - 473
SICI:
0022-3956(1994)28:5<461:AAODDR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; RAT-BRAIN; OVARIECTOMIZED RATS; MOLECULAR-CLONING; GROWTH-HORMONE; RELEASE; D1; THYROTROPIN; INHIBITION; PROLACTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
H. Wetzel et al., "ACUTE ANTAGONISM OF DOPAMINE D-2-LIKE RECEPTORS BY AMISULPRIDE - EFFECTS ON HORMONE-SECRETION IN HEALTHY-VOLUNTEERS", Journal of Psychiatric Research, 28(5), 1994, pp. 461-473

Abstract

Amisulpride is a selective D-2-like dopamine receptor antagonist witha high affinity for the cloned D-2 and D-3 receptors. At low;loses itmay improve depressive and negative schizophrenic symptoms whereas antipsychotic effects on positive schizophrenic symptomatology require higher dosages. Acute endocrine effects were studied for two doses of amisulpride with regard to the daytime secretion of prolactin, thyroidea stimulating hormone (TSH), growth hormone (GH), luteinizing hormone (LH) and cortisol. Amisulpride was administered i.v. to eight healthy male volunteers in a single-blind trial under a randomized cross-over,placebo-controlled design using doses of 20 mg or 100 mg, or saline. The drug was injected at 09:00 h, and plasma samples were withdrawn from 08:30 h to 16:00 h at intervals of 15 and 30 min, respectively. At both dosages, prolactin was significantly elevated to the eight- to ten-fold of baseline levels. Likewise, a significant 50% elevation of TSH concentrations with a trend to a greater increase under the 100 mg dose was observed. Plasma levels of LH and cortisol were not significantly affected by amisulpride. With regard to GH secretion, there was a trend to a decrease only with the 20 mg dose. These results indicate that the neuroendocrinological side-effect profile of acute amisulprideadministration may be similar to conventional neuroleptics, and that there are only minor dose-dependent differential effects on hormone secretion in the dose range investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:10:08