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Titolo:
FOAM CELL APOPTOSIS AND THE DEVELOPMENT OF THE LIPID CORE OF HUMAN ATHEROSCLEROSIS
Autore:
HEGYI L; SKEPPER JN; CARY NRB; MITCHINSON MJ;
Indirizzi:
UNIV CAMBRIDGE,DEPT PATHOL,DIV CELLULAR PATHOL,TENNIS COURT RD CAMBRIDGE CB2 1QP ENGLAND UNIV CAMBRIDGE,DEPT PATHOL,DIV CELLULAR PATHOL CAMBRIDGE CB2 1QP ENGLAND UNIV CAMBRIDGE,DEPT ANAT,MULTIIMAGING CTR CAMBRIDGE CB2 3DY ENGLAND PAPWORTH HOSP,DEPT PATHOL CAMBRIDGE CB3 8RE ENGLAND
Titolo Testata:
Journal of pathology
fascicolo: 4, volume: 180, anno: 1996,
pagine: 423 - 429
SICI:
0022-3417(1996)180:4<423:FCAATD>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; MOUSE PERITONEAL-MACROPHAGES; HUMAN MONOCYTE-MACROPHAGES; SMOOTH-MUSCLE CELLS; DEATH; IDENTIFICATION; PROLIFERATION; CHOLESTEROL; OXYSTEROLS; INDUCTION;
Keywords:
FOAM CELL; MACROPHAGE; ATHEROSCLEROSIS (HUMAN); APOPTOSIS; LIPID CORE; PCNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
L. Hegyi et al., "FOAM CELL APOPTOSIS AND THE DEVELOPMENT OF THE LIPID CORE OF HUMAN ATHEROSCLEROSIS", Journal of pathology, 180(4), 1996, pp. 423-429

Abstract

A characteristic feature of the advanced atherosclerotic lesion is the acellular lipid core, which appears to result at least partly from the death of macrophage foam cells. This study shows that foam cell death at the edge of the lipid core includes both necrosis and apoptosis and that remnants of apoptotic nuclei are present within the lipid core. Apoptotic cells were identified by transmission electron microscopyand by nick end-labelling using terminal deoxynucleotidyl transferase(TUNEL). Some TUNEL-positive cells also expressed proliferating cell nuclear antigen (PCNA), The cause of foam cell death in atherogenesis is unknown, but oxidized low-density lipoprotein (LDL) can cause macrophage apoptosis in vitro and might therefore play a role in the formation and enlargement of the lipid core.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/02/20 alle ore 08:06:30