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Titolo:
RESISTANCE TO ARSENIC COMPOUNDS IN MICROORGANISMS
Autore:
CERVANTES C; JI GY; RAMIREZ JL; SILVER S;
Indirizzi:
UNIV MICHOACANA,INST INVEST QUIM BIOL MORELIA 58240 MICHOACAN MEXICO UNIV ILLINOIS,COLL MED,DEPT MICROBIOL & IMMUNOL MC790 CHICAGO IL 60612 UNIV AUTONOMA SAN LUIS POTOSI,FAC MED SAN LUIS POTOSI MEXICO
Titolo Testata:
FEMS microbiology reviews
fascicolo: 4, volume: 15, anno: 1994,
pagine: 355 - 367
SICI:
0168-6445(1994)15:4<355:RTACIM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMID-DETERMINED RESISTANCE; ACTING REGULATORY PROTEIN; HEAVY-METAL RESISTANCE; ESCHERICHIA-COLI; PSEUDOMONAS-AERUGINOSA; MULTIDRUG RESISTANCE; SACCHAROMYCES-CEREVISIAE; NUCLEOTIDE-SEQUENCE; PHOSPHATE-TRANSPORT; P-GLYCOPROTEIN;
Keywords:
ARSENIC EFFLUX; TOXICITY; RESISTANCE; PLASMID RESISTANCES; FUNGI; ALGAE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
119
Recensione:
Indirizzi per estratti:
Citazione:
C. Cervantes et al., "RESISTANCE TO ARSENIC COMPOUNDS IN MICROORGANISMS", FEMS microbiology reviews, 15(4), 1994, pp. 355-367

Abstract

Arsenic ions, frequently present as environmental pollutants, are very toxic for most microorganisms. Some microbial strains possess genetic determinants that confer resistance. In bacteria, these determinantsare often found on plasmids, which has facilitated their study at themolecular level. Bacterial plasmids conferring arsenic resistance encode specific efflux pumps able to extrude arsenic from the cell cytoplasm thus lowering the intracellular concentration of the toxic ions. In Gram-negative bacteria, the efflux pump consists of a two-component ATPase complex. ArsA is the ATPase subunit and is associated with an integral membrane subunit, ArsB. Arsenate is enzymatically reduced to arsenite (the substrate of ArsB and the activator of ArsA) by the smallcytoplasmic ArsC polypeptide. In Gram-positive bacteria, comparable arsB and arsC genes (and proteins) are found, but arsA is missing. In addition to the wide spread plasmid arsenic resistance determinant, a few bacteria confer resistance to arsenite with a separate determinant for enzymatic oxidation of more-toxic arsenite to less-toxic arsenate. In contrast to the detailed information on the mechanisms of arsenic resistance in bacteria, little work has been reported on this subject in algae and fungi.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:00:52