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Titolo:
T-CELL RECEPTOR V-BETA REPERTOIRES OF ANGIOIMMUNOBLASTIC LYMPHADENOPATHY-LIKE T-CELL LYMPHOMA
Autore:
ARAKI A; TANIGUCHI M; MIKATA A;
Indirizzi:
CHIBA UNIV,SCH MED,DEPT RADIOL,CHUO KU,1-8-1 INOHANA CHIBA 260 JAPAN
Titolo Testata:
Leukemia & lymphoma
fascicolo: 1-2, volume: 16, anno: 1994,
pagine: 135 - 140
SICI:
1042-8194(1994)16:1-2<135:TRVROA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Keywords:
ANGIOIMMUNOBLASTIC LYMPHADENOPATHY-LIKE T CELL LYMPHOMA; V-BETA REPERTOIRE; POLYMERASE CHAIN REACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
A. Araki et al., "T-CELL RECEPTOR V-BETA REPERTOIRES OF ANGIOIMMUNOBLASTIC LYMPHADENOPATHY-LIKE T-CELL LYMPHOMA", Leukemia & lymphoma, 16(1-2), 1994, pp. 135-140

Abstract

To elucidate the pathogenesis of angioimmunoblastic lymphadenopathy-like T cell lymphoma (AILD-T) we investigated the T cell receptor V beta gene repertoires of four AILD-Ts and compared them with those of other histological types of lymphomas and three cases with reactive disorders. All lymphoma patients had rearrangement bands detected by Southern blot analysis. Only 1 of the 4 cases of AILD-T showed a single predominant usage of V beta 20 gene by PCR with 20 different V beta specific primers and the others had repertoires somewhat restricted but similar to reactive lesions. Subsequent sequencing of this PCR product revealed that only 2 of 7 clones were identical. These results suggest the monoclonal malignant cells in AILD-T are scant and that the infiltrating T cells show a reactive pattern. In the only AILD-T case with a single dominant V beta usage, the relationships of this repertoire and lymphoma cells seems to be of some consequence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:33:48