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Titolo:
NEPHRON TARGET SITES IN CHRONIC EXPOSURE TO LEAD
Autore:
FELS LM; HERBORT C; PERGANDE M; JUNG K; HOTTER G; ROSELLO J; GELPI E; MUTTI A; DEBROE M; STOLTE H;
Indirizzi:
HANNOVER MED SCH,DIV NEPHROL,KONSTANTY GUTSCHOW STR 8 D-30625 HANNOVER GERMANY HUMBOLDT UNIV BERLIN,HOSP CHARITE,DEPT UROL BERLIN GERMANY CSIC,DEPT BIOMED ANAL,MOLEC PATHOL & BIOCHEM INFLAMMAT UNIT BARCELONASPAIN UNIV PARMA,SCH MED,IND TOXICOL LAB I-43100 PARMA ITALY UNIV ANTWERP,DEPT NEPHROL HYPERTENS B-2020 ANTWERP BELGIUM
Titolo Testata:
Nephrology, dialysis, transplantation
fascicolo: 12, volume: 9, anno: 1994,
pagine: 1740 - 1746
SICI:
0931-0509(1994)9:12<1740:NTSICE>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY-EXCRETION; INDUSTRIAL POLLUTANTS; FIBRONECTIN; HYPERTENSION; INDICATOR; PROTEIN; MARKERS; LAMININ;
Keywords:
EICOSANOIDS; FIBRONECTIN; GLOMERULUS; LEAD NEPHROPATHY; TUBULAR APPARATUS; TUBULAR ANTIGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
L.M. Fels et al., "NEPHRON TARGET SITES IN CHRONIC EXPOSURE TO LEAD", Nephrology, dialysis, transplantation, 9(12), 1994, pp. 1740-1746

Abstract

With established urinary markers of kidney integrity the early renal effects of lead have previously been considered to be mainly tubular or tubulointerstitial. In a cross-sectional study on 81 male lead-exposed workers and 45 age-matched controls (median blood lead concentrations 2.03 and 0.34 mu mol/l respectively) not only well-established but also new urinary markers of renal integrity preferentially or exclusively located along the different nephron segments were analysed. Markers related to the glomerulus were 6-keto-prostaglandin(1 alpha), thromboxane B-2, mainly produced in the glomerulus, and the extracellular matrix protein fibronectin. Markers of the proximal tubule were the brush-border antigens BBA, BB50, and HF5 and the intestinal alkaline phosphatase. Prostaglandin E(2) and F-2 alpha, preferentially synthesized in the collecting duct and medullary interstitial cells, served as markers of these more distal nephron segments. In contrast to previous studies on the early phase of lead nephrotoxicity, not only tubular but also glomerular involvement could be shown in the study presented here by increases in the median values of 6-keto-prostaglandin(1 alpha), and decreases in fibronectin. The proximal tubular markers intestinal alkaline phosphatase and BBA confirmed that this particular segment of the nephron is affected by lead. Effects on the collecting tubule or medullary interstitial cells could also be observed. It is concluded that lead affects both the glomerulus and the tubular apparatus and that combinations of new and established markers could be valuable for a better definition and early detection of lead nephropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:51:09