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Titolo:
EFFECT OF GHRP-6 AND GHRH ON GH SECRETION IN RATS FOLLOWING CHRONIC GLUCOCORTICOID TREATMENT
Autore:
VOLTZ DM; PIERING AW; MAGESTRO M; GIUSTINA A; WEHRENBERG WB;
Indirizzi:
UNIV WISCONSIN,DEPT HLTH SCI MILWAUKEE WI 53211 UNIV WISCONSIN,DEPT BIOL SCI MILWAUKEE WI 53211 UNIV BRESCIA,CATTEDRA CLIN MED BRESCIA ITALY
Titolo Testata:
Life sciences
fascicolo: 7, volume: 56, anno: 1995,
pagine: 491 - 497
SICI:
0024-3205(1995)56:7<491:EOGAGO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-HORMONE SECRETION; INVIVO ACTIVITY; PITUITARY; HEXAPEPTIDE; PEPTIDE; HIS-DTRP-ALA-TRP-DPHE-LYS-NH2; INHIBITION; ANTIBODIES; RESPONSES; CULTURE;
Keywords:
GROWTH HORMONE; GLUCOCORTICOID; GROWTH HORMONE-RELEASING PEPTIDE; SOMATOSTATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
D.M. Voltz et al., "EFFECT OF GHRP-6 AND GHRH ON GH SECRETION IN RATS FOLLOWING CHRONIC GLUCOCORTICOID TREATMENT", Life sciences, 56(7), 1995, pp. 491-497

Abstract

The aim of our study was to investigate the effects of His-DTrp-Ala-Trp-Phe-Lys-NH2 (GHRP-6) on baseline and growth hormone-releasing hormone (GHRH) stimulated growth hormone (GH) release in conscious, freely-moving rats receiving chronic glucocorticoid treatment. Animals were treated daily for seven days with either vehicle or dexamethasone (dex,40 mu g/day). On the day of experimentation, rats received an iv injection of saline or GHRP-6 followed 15 min later by an iv injection of saline or rat GHRH. Three doses of GHRP-6 were evaluated, 1 mu g, 4 mug and 25 mu g/kg; one dose of GHRH was evaluated, 500 ng/kg. GHRP-6 increased plasma GH levels over baseline concentrations in a dose-dependant fashion both in vehicle- and dex-treated rats. The GH response toGHRP-6 and GHRH was significantly less in dex-treated rats as compared to vehicle-treated rats. The combined administration of GHRP-6 and GHRH did not result in any change in plasma GH levels which could not be predicted from the administration of either peptide alone. Our results show that GHRP-6 is able to stimulate GH secretion in glucocorticoid-treated rats but it is unable to counteract the glucocorticoid-induced inhibition of GH secretion.

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Documento generato il 13/07/20 alle ore 18:01:51