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Titolo:
ENHANCEMENT OF DELAYED-HYPERSENSITIVITY INFLAMMATORY REACTIONS IN GUINEA-PIG SKIN BY 12(R)-HYDROXY-5,8,14-EICOSATRIENOIC ACID
Autore:
CONNERS MS; SCHWARTZMAN ML; QUAN X; HEILMAN E; CHAUHAN K; FALCK JR; GODFREY HP;
Indirizzi:
NEW YORK MED COLL,DEPT PHARMACOL,BAS SCI BLDG VALHALLA NY 10595 NEW YORK MED COLL,DEPT PHARMACOL VALHALLA NY 10595 NEW YORK MED COLL,DEPT EXPTL PATHOL VALHALLA NY 10595 SUNY HLTH SCI CTR,DEPT DERMATOL BROOKLYN NY 11203 SUNY HLTH SCI CTR,DEPT PATHOL BROOKLYN NY 11203 UNIV TEXAS,SW MED CTR,DEPT MOLEC GENET DALLAS TX 75235
Titolo Testata:
Journal of investigative dermatology
fascicolo: 1, volume: 104, anno: 1995,
pagine: 47 - 51
SICI:
0022-202X(1995)104:1<47:EODIRI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARACHIDONIC-ACID; FATTY-ACIDS; 12(R)-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; 12-HYDROXY-5,8,10,14-EICOSATETRAENOIC ACID; 12(R)-HYDROXYEICOSATRIENOIC ACID; POLYMORPHONUCLEAR LEUKOCYTES; CORNEAL EPITHELIUM; METABOLISM; LIPOXYGENASE; MOUSE;
Keywords:
LIPOXYGENASE; CYTOCHROME P450; ARACHIDONIC ACID; EICOSANOIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Conners et al., "ENHANCEMENT OF DELAYED-HYPERSENSITIVITY INFLAMMATORY REACTIONS IN GUINEA-PIG SKIN BY 12(R)-HYDROXY-5,8,14-EICOSATRIENOIC ACID", Journal of investigative dermatology, 104(1), 1995, pp. 47-51

Abstract

Delayed-type hypersensitivity (DTH) reactions are initiated by sensitized T cells, Their progression is dependent upon the local release ofvarious autacoids, including cytokines and eicosanoids, by T cells, infiltrating inflammatory cells, and resident tissue cells, 12(R)-hydroxy-5,8,14-eicosatrienoic acid [12(R)-HETrE], an eicosanoid produced byskin and cornea, possesses potent proinflammatory properties at picomolar concentrations including vasodilation, increase in membrane permeability, neutrophil chemotaxis, and angiogenesis, Because DTH reactions are associated with many of these same phenomena, we examined the effect of 12(R)-HETrE and related 12-hydroxyeicosanoids on the expression of DTH to purified protein derivative of tuberculin in sensitized guinea pigs, In the absence of purified protein derivative of tuberculin, none of the eicosanoids evoked erythema or edema after intradermal injection at doses up to 100 pmol, When injected together with purifiedprotein derivative of tuberculin, 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid [12(R)-HETE], but not its enantiomer 12(S)-HETE, significantly inhibited macroscopic expression of delayed reactivity (erythema) only at the highest dose tested, 10 pmol, In contrast, 12(R)-HETrE significantly enhanced expression of DTH at doses between 1 fmol and 1 pmol (50% and 30% increases above control, respectively), Its stereoisomer, 12(S)-HETrE, did not enhance DTH at any tested dose, but was able to block the activity of 12(R)-HETrE when injected simultaneously, Enhancement or inhibition of visible skin responses was not associated with qualitative or quantitative changes in cellular infiltrates at the reaction site, 12(R)-HETrE had no effect on the nonimmunologic inflammatory skin reaction induced by phorbol myristate acetate, suggesting selectivity toward DTH. We conclude that 12(R)-HETrE enhances DTH via ayet to be determined mechanism and that its stereoisomer, 12(S)-HETrE, may be a useful antagonist for studying the inflammatory actions of this eicosanoid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 02:21:02