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Titolo:
LONG-TERM EFFICACY OF ACTIVE POSTEXPOSURE IMMUNIZATION OF INFANTS FORPREVENTION OF HEPATITIS-B VIRUS-INFECTION
Autore:
XU ZY; DUAN SC; MARGOLIS HS; PURCELL RH; OUYANG PY; COLEMAN PJ; ZHUANG YL; XU HF; QIAN SG; ZHU QR; WAN CY; LIU CB; GUN ZL; HUANG CH; ZHANG ZJ; REN SL; FRANCIS DP; MAYNARD JE; GERIN JL; HADLER SC; FIELDS HA; JOHNSON L;
Indirizzi:
CTR DIS CONTROL & PREVENT,DIV VIRAL & RICKETTSIAL DIS,WHO ATLANTA GA 30333 SHANGHAI MED UNIV,PEDIAT HOSP,DEPT EPIDEMIOL SHANGHAI PEOPLES R CHINA SHANGHAI MED UNIV,GYNECOL & OBSTET HOSP SHANGHAI PEOPLES R CHINA NATL ACAD PREVENT MED,INST VIROL BEIJING PEOPLES R CHINA BEIJING INST VACCINE & SERUM BEIJING PEOPLES R CHINA CTR DIS CONTROL & PREVENT,DIV VIRAL & RICKETTSIAL DIS,WHO ATLANTA GA 30333
Titolo Testata:
The Journal of infectious diseases
fascicolo: 1, volume: 171, anno: 1995,
pagine: 54 - 60
SICI:
0022-1899(1995)171:1<54:LEOAPI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE GLOBULIN; CARRIER MOTHERS; VACCINE; TRANSMISSION; HBEAG; STATE; HBSAG; BORN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
Z.Y. Xu et al., "LONG-TERM EFFICACY OF ACTIVE POSTEXPOSURE IMMUNIZATION OF INFANTS FORPREVENTION OF HEPATITIS-B VIRUS-INFECTION", The Journal of infectious diseases, 171(1), 1995, pp. 54-60

Abstract

Perinatal transmission of hepatitis B virus (HBV) contributes to the high prevalence of chronic infection in China and many other countries. In a placebo-controlled trial among 166 infants, the 12-month efficacy of active postexposure prophylaxis to prevent chronic perinatal HBVinfection varied by vaccine (range, 45%-89%). In a 5-year follow-up study, 2 additional infants became chronically infected with HBV, and the efficacy of active prophylaxis was estimated to be 38% and 72% for the two vaccines at 5 years. In addition, 80% of immunized infants continued to have protective levels of antibody at the end of 5 years. However, among 27 infants who received passive-active immunoprophylaxis with high-dose hepatitis B immune globulin, only 60% (11/19) had protective antibody levels. These data indicate that active postexposure immunization initiated soon after birth continues to provide protection during early childhood when there is a high risk of chronic HBV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:28:15