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Titolo:
WASHOUT AND REDISTRIBUTION BETWEEN IMMEDIATE AND 2-HOUR MYOCARDIAL IMAGES USING TC-99M-SESTAMIBI
Autore:
RICHTER WS; CORDES M; CALDER D; EICHSTAEDT H; FELIX R;
Indirizzi:
FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,STRAHLENKLIN & POLIKLIN,AUGUSTENBURGER PLATZ 1 D-13353 BERLIN GERMANY
Titolo Testata:
European journal of nuclear medicine
fascicolo: 1, volume: 22, anno: 1995,
pagine: 49 - 55
SICI:
0340-6997(1995)22:1<49:WARBIA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; METHOXY ISOBUTYL ISONITRILE; TL-201; PERFUSION; SCINTIGRAPHY; INFARCTION; VIABILITY; KINETICS; REST;
Keywords:
TC-99M SESTAMIBI; TRACER WASHOUT; TRACER REDISTRIBUTION; EXERCISE STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
W.S. Richter et al., "WASHOUT AND REDISTRIBUTION BETWEEN IMMEDIATE AND 2-HOUR MYOCARDIAL IMAGES USING TC-99M-SESTAMIBI", European journal of nuclear medicine, 22(1), 1995, pp. 49-55

Abstract

The aim of this study was to assess whether a clinically relevant change in myocardial sestamibi activity could be documented within the first 120 min following injection (p.i.). In 17 patients planar anteriorimaging of the heart was performed 5 min and 120 min p.i. During thistime interval, mean decay-corrected myocardial activity declined to 77.9%+/-9.7% after stress and to 85.7%+/-7.9% after injection at rest (P<0.05). In 19 patients with angiographically documented coronary artery disease, single-photon emission tomography was performed 5 min and 120 min after injection at maximum stress. For analysis, sestamibi activity was scored semiquantitatively in six left ventricular segments. Furthermore, sestamibi uptake was assessed quantitatively using a circumferential profile method. In 35 of 114 segments the score improved within 120 min p.i. (early fillin); in these segments relative sestamibi activity rose from 69.9%+/-22.5% to 74.5%+/-20.8% (P<0.01). In five patients this early fill-in was the only sign of exercise-induced hypoperfusion. In 7 of 114 segments the score deteriorated 120 min p.i. (early tracer washout); in these segments relative sestamibi activity declined from 85.6%+/-9.9% to 80.1%+/-10.7% (P<0.02). In three of four patients with early tracer washout the corresponding coronary artery was significantly narrowed. In conclusion, a global myocardial sestamibiwashout was registered within the first 120 min after injection. A fill-in of initial defects as well as an early tracer loss could be detected in a relevant number of patients with chronic coronary artery disease during the first 2 h p.i. In these patients the extent of detected reversible perfusion abnormality depends on the chosen time intervalbetween injection and imaging. The results of this study suggest thatexercise imaging should be started immediately after injection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:18:52