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Titolo:
OLD RATS ARE UNRESPONSIVE TO THE BEHAVIORAL-EFFECTS OF ADRENOCORTICOTROPIN
Autore:
POGGIOLI R; BENELLI A; ARLETTI R; VERGONI AV; MENOZZI B; BERTOLINI A;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,VIA G CAMPI 287 I-41100 MODENA ITALY
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 271, anno: 1994,
pagine: 253 - 257
SICI:
0014-2999(1994)271:2-3<253:ORAUTT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING HORMONE; ALPHA-MSH; PERIPHERAL-NERVE; ACTH; RECOVERY; BRAIN; CORTICOTROPIN; REGENERATION; MELANOCORTINS; RECEPTORS;
Keywords:
AGING; ACTH (ADRENOCORTICOTROPIN); MELANOCORTIN; GROOMING; STRETCHING; YAWNING; PENILE ERECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
R. Poggioli et al., "OLD RATS ARE UNRESPONSIVE TO THE BEHAVIORAL-EFFECTS OF ADRENOCORTICOTROPIN", European journal of pharmacology, 271(2-3), 1994, pp. 253-257

Abstract

In 28 month-old male rats, the i.c.v. injection of adrenocorticotropin [ACTH-(1-24)] (4 mu g/rat) did not induce the typical behavioral syndrome (excessive grooming, stretching, yawning, penile erections). This indicates that the behavioral effects of melanocortins are age-dependent, suggesting either an aging-linked impairment of the nervous circuitries involved or a reduction of the number (or affinity, or both) of the brain melanocortin receptors in the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 10:55:31