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Titolo:
LYSIS OF HUMAN MACROPHAGES BY CYTOLYTIC CD4(-CELLS FAILS TO AFFECT SURVIVAL OF INTRACELLULAR MYCOBACTERIUM-BOVIS BACILLE CALMETTE-GUERIN (BCG)() T)
Autore:
FAZAL N; LAMMAS DA; RAHELU M; PITHIE AD; GASTON JSH; KUMARARATNE DS;
Indirizzi:
UNIV BIRMINGHAM,SCH MED,DEPT IMMUNOL,VINCENT DR BIRMINGHAM B15 2TT W MIDLANDS ENGLAND UNIV BIRMINGHAM,SCH MED,DEPT IMMUNOL BIRMINGHAM B15 2TT W MIDLANDS ENGLAND UNIV BIRMINGHAM,DEPT INFECT BIRMINGHAM B15 2TT W MIDLANDS ENGLAND UNIV BIRMINGHAM,DEPT RHEUMATOL BIRMINGHAM B15 2TT W MIDLANDS ENGLAND
Titolo Testata:
Clinical and experimental immunology
fascicolo: 1, volume: 99, anno: 1995,
pagine: 82 - 89
SICI:
0009-9104(1995)99:1<82:LOHMBC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK PROTEIN; TOXIC LYMPHOCYTES-T; HUMAN-MONOCYTES; TUBERCULOSIS; GENERATION; GAMMA; RECOGNITION; INDUCTION; LINES;
Keywords:
MYCOBACTERIA; CYTOLYTIC T CELLS; CD4(+); HUMAN MACROPHAGES; INTRACELLULAR SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
N. Fazal et al., "LYSIS OF HUMAN MACROPHAGES BY CYTOLYTIC CD4(-CELLS FAILS TO AFFECT SURVIVAL OF INTRACELLULAR MYCOBACTERIUM-BOVIS BACILLE CALMETTE-GUERIN (BCG)() T)", Clinical and experimental immunology, 99(1), 1995, pp. 82-89

Abstract

Human CD4(+), mycobacteria-specific, cytolytic T cell clones were used to lyse BCG-infected macrophages, and the effect on the subsequent growth and viability of the organisms was examined. The survival of released bacteria following cell lysis was assessed by both H-3-uridine labelling and colony-forming unit (CFU) estimation. The results indicate that even when effective antigen-specific or lectin-mediated cytolysis of the infected macrophages was achieved, there was no evidence fora direct mycobactericidal effect on the intracellular bacteria. This remained the case even if the period of co-culture of T cells and macrophages was extended up to 48 h. Pretreatment of the macrophages with interferon-gamma (IFN-gamma) was not able to act together with T cell-mediated lysis to produce inhibition of mycobacterial growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:32:33