Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THE EFFECT OF INTRAVENOUS-INFUSION TIME ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF THE SAME TOTAL-DOSE OF AZOSEMIDE IN RABBITS
Autore:
PARK KJ; YOON WH; SHIN WG; LEE MG;
Indirizzi:
SEOUL NATL UNIV,COLL PHARM,KWANAK GU,SAN 56-1 SEOUL 151742 SOUTH KOREA SEOUL NATL UNIV,COLL PHARM,KWANAK GU SEOUL 151742 SOUTH KOREA SEOUL NATL UNIV HOSP,DEPT PHARM,CHONGRO GU SEOUL 110744 SOUTH KOREA
Titolo Testata:
Biopharmaceutics & drug disposition
fascicolo: 1, volume: 18, anno: 1997,
pagine: 41 - 52
SICI:
0142-2782(1997)18:1<41:TEOITO>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
THERAPEUTIC USE; BUMETANIDE; FUROSEMIDE; ABSORPTION; PLASMA; BLOOD; URINE; RATS;
Keywords:
SAME TOTAL DOSE OF AZOSEMIDE; DIFFERENT LENGTHS OF INFUSION TIME; PHARMACOKINETICS; PHARMACODYNAMICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
K.J. Park et al., "THE EFFECT OF INTRAVENOUS-INFUSION TIME ON THE PHARMACOKINETICS AND PHARMACODYNAMICS OF THE SAME TOTAL-DOSE OF AZOSEMIDE IN RABBITS", Biopharmaceutics & drug disposition, 18(1), 1997, pp. 41-52

Abstract

The pharmacokinetics and pharmacodynamics of azosemide were evaluatedafter intravenous (IV) administration of the same total dose of azosemide, 1 mg kg(-1), in different infusion times, 1 min (treatment I) and 4h (treatment II) to rabbits (n=5, each). The loss of water and electrolytes in urine induced by azosemide was immediately replaced with infusion of equal volume of lactated Ringer's solution. Some pharmacokinetic parameters of azosemide were different between treatments I and II. For example, the mean value of terminal half-life (70.5 versus 107min), total body clearance (5.88 versus 8.32 mL min(-1)kg(-1)), renalclearance (3.45 versus 6.51 mL min(-1)kg(-1)), and mean residence time (18.5 versus 31.7 min) increased significantly in treatment II. The 8 h urine output (236 versus 733 mL) and 8 h urinary excretion of sodium (29.2 versus 76.4 mmol) and chloride (27.5 versus 78.9 mmol) increased significantly in treatment IT although the total amount of 8 h urinary excretion of unchanged azosemide increased by only 15% in treatment II. This could be due to the fact that the urinary excretion rates of azosemide in treatment II remained for a longer period of time close to the maximally efficient urinary excretion rates of azosemide for both urine output and urinary excretion rates of sodium than in treatment I. Plasma concentrations of azosemide and hourly urine output and hourly urinary excretion of azosemide, sodium, potassium, and chlorideduring the apparent steady state (between 2 and 4 h) in treatment II were fairly constant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:30:10