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Titolo:
SERUM APOLIPOPROTEIN-A-I AND APOLIPOPROTEIN-B AS MARKERS OF CORONARY-ARTERY-DISEASE RISK IN EARLY-LIFE - THE BOGALUSA HEART-STUDY
Autore:
SRINIVASAN SR; BERENSON GS;
Indirizzi:
TULANE UNIV,SCH PUBL HLTH & TROP MED,TULANE CTR CARDIOVASC HLTH,1430 TULANE AVE,SL29 NEW ORLEANS LA 70112 TULANE UNIV,SCH PUBL HLTH & TROP MED,TULANE CTR CARDIOVASC HLTH NEW ORLEANS LA 70112
Titolo Testata:
Clinical chemistry
fascicolo: 1, volume: 41, anno: 1995,
pagine: 159 - 164
SICI:
0009-9147(1995)41:1<159:SAAAAM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; MYOCARDIAL-INFARCTION; BIRACIAL COMMUNITY; LARGE PEDIGREE; E POLYMORPHISM; CHOLESTEROL; CHILDREN; ATHEROSCLEROSIS; PROTEIN; FRAMINGHAM;
Keywords:
EPIDEMIOLOGY; RACE-RELATED EFFECTS; SEX- AND AGE-RELATED EFFECTS; PEDIATRIC CHEMISTRY; GENETIC STUDIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
S.R. Srinivasan e G.S. Berenson, "SERUM APOLIPOPROTEIN-A-I AND APOLIPOPROTEIN-B AS MARKERS OF CORONARY-ARTERY-DISEASE RISK IN EARLY-LIFE - THE BOGALUSA HEART-STUDY", Clinical chemistry, 41(1), 1995, pp. 159-164

Abstract

The functional properties of the apolipoproteins (apoB and apoA-l) governing lipoprotein metabolism make these variables conceptually important as markers for coronary artery disease risk. This aspect was examined in a biracial (black-white) population of children as part of theBogalusa Heart Study. White children, especially boys, showed lower concentrations of apoA-l and ratios of cholesterol to apoB within low-density lipoprotein (LDL) than did black children. Persistence of apoB concentrations over time, coupled with its strong linkage with apoB gene locus, underscores the value of detecting apoB excess early in life. Further, the impact of apoE genotypes on apoB and apoA-l levels is already evident in childhood. We found that, as a screening test for detecting increased LDL cholesterol, apoB is superior to total cholesterol. Low values for apoA-l concentration, the apoA-l to apoB ratio, andLDL cholesterol to apoB ratio in children are strongly related to parental incidence of myocardial infarction; no such relationship is seenwith respect to lipoprotein cholesterols. Thus, expanding screening strategies might be useful for identifying individuals with adverse apolipoprotein profiles early in life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/08/20 alle ore 23:19:02