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Titolo:
MULTICENTER EVALUATION OF ENHANCED CHEMILUMINESCENCE LABELED-ANTIBODYIMMUNOASSAY (AMERLITE-MAB(TM)) FOR FREE-THYROXINE
Autore:
CHRISTOFIDES ND; SHEEHAN CP;
Indirizzi:
KODAK CLIN DIAGNOST LTD,CARDIFF LABS,IMMUNOASSAY DEV AMESHAM ENGLAND
Titolo Testata:
Clinical chemistry
fascicolo: 1, volume: 41, anno: 1995,
pagine: 24 - 31
SICI:
0009-9147(1995)41:1<24:MEOECL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE NONTHYROIDAL ILLNESS; THYROID-HORMONE BINDING; SERUM FREE-THYROXINE; EQUILIBRIUM DIALYSIS; FREE TRIIODOTHYRONINE; UNDILUTED SERUM; FATTY-ACIDS; ONE-STEP; ASSAY; RADIOIMMUNOASSAY;
Keywords:
IMMUNOENZYMATIC ASSAY; PRECISION; BINDING PROTEINS; THYROID HORMONES IN NONTHYROIDAL ILLNESS; PREGNANCY; AGE-RELATED EFFECTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
N.D. Christofides e C.P. Sheehan, "MULTICENTER EVALUATION OF ENHANCED CHEMILUMINESCENCE LABELED-ANTIBODYIMMUNOASSAY (AMERLITE-MAB(TM)) FOR FREE-THYROXINE", Clinical chemistry, 41(1), 1995, pp. 24-31

Abstract

The technical and diagnostic performance of the Amerlite-MAB(TM) enhanced luminescence assay for free thyroxine (FT4) was assessed in a multicenter evaluation trial. The euthyroid central 95% reference range for FT4 (1393 subjects) was 11.5-27.7 pmol/L (by cumulative frequency plot with two-tailed 2.5% cutoffs). Results (y) agreed with those of similar radioactive method (Amerlex-MAB(TM) FT4) (x): y = 1.06 x + 0.54, S-ylx = 335.5, n = 235). Mean within-assay precision (CV) in six centers was 5.7% at 6 pmol/L and 2.6% at 51 pmol/L FT4; between-assay precision (CV) was 7.2% and 3.6%, respectively. Diagnostic performance was assessed in all patient groups usually encountered, including those with nonthyroidal illness and extreme binding-protein anomalies. In elderly euthyroid subjects, the proportion of above-normal FT4 values exceeded that in younger age-groups. These increases often accompanied normal estimates of thyrotropin and, in some cases, might have arisen by interference from medication that is taken more often by the elderly.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:27:45