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Titolo:
CENTRAL ACTIONS OF PEPTIDE AND NONPEPTIDE GROWTH-HORMONE SECRETAGOGUES IN THE RAT
Autore:
DICKSON SL; LENG G; DYBALL REJ; SMITH RG;
Indirizzi:
UNIV LONDON KINGS COLL,ANAT & HUMAN BIOL GRP LONDON WC2R 2LS ENGLAND BABRAHAM INST,DEPT NEUROBIOL CAMBRIDGE ENGLAND UNIV CAMBRIDGE,DEPT ANAT CAMBRIDGE ENGLAND MERCK RES LABS,DEPT PHYSIOL & BIOCHEM RAHWAY NJ 00000
Titolo Testata:
Neuroendocrinology
fascicolo: 1, volume: 61, anno: 1995,
pagine: 36 - 43
SICI:
0028-3835(1995)61:1<36:CAOPAN>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
(GH)-RELEASING FACTOR; PITUITARY-CELLS; NEURONS; RELEASE; SOMATOSTATIN; HIS-D-TRP-ALA-TRP-D-PHE-LYS-NH2; LOCALIZATION; HEXAPEPTIDE; SECRETION; L-692,429;
Keywords:
GROWTH HORMONE; ARCUATE NUCLEUS; GROWTH HORMONE-RELEASING HORMONE; GROWTH HORMONE-RELEASING PEPTIDE; C-FOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
S.L. Dickson et al., "CENTRAL ACTIONS OF PEPTIDE AND NONPEPTIDE GROWTH-HORMONE SECRETAGOGUES IN THE RAT", Neuroendocrinology, 61(1), 1995, pp. 36-43

Abstract

Evidence for a central site of action of growth-hormone-releasing peptide (GHRP-6) was sought by (1) counting the number of Fos-positive nuclei within the brain following intracerebroventricular or intravenousinjection of peptide and non-peptide GH secretagogues and (2) characterizing the electrophysiological responses of neuroendocrine arcuate neurones (recorded in vivo) following intravenous injection of GHRP-6. Conscious male rats were chronically implanted with intracerebroventricular or intravenous catheters. Dense nuclear Fos staining was inducedthroughout the ventral arcuate nucleus of rats injected intracerebroventricularly with low doses of GHRP-6 but not in rats injected with the endogenous GH-releasing hormone GHRH or in vehicle-treated controls. The non-peptidyl GH secretagogues L-692,585 and Lr 692,429 also induced Fos expression in the arcuate nucleus, and the pattern of distribution was similar to that described for GHRP-6. No increase in Fos expression was observed in rats given a systemic injection of a high dose of GHRH. In pentobarbitone-anaesthetized male rats, the effects of intravenous injection of GHRP-6 on the electrical activity of arcuate neurones was predominantly excitatory for putative neuroendocrine cells and inhibitory for the remaining unidentified cells. These results suggest that (1) GHRP-6 and nonpeptidyl GH secretagogues have a central site of action involving the activation nucleus of a subpopulation of arcuate neurones and (2) this action is not mimicked by the central or peripheral effects of GHRH.

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Documento generato il 09/07/20 alle ore 01:06:51