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Titolo:
PLASMA-LEVELS OF LUTEINIZING-HORMONE DURING HYPERPROLACTINEMIA - RESPONSE TO CENTRAL ADMINISTRATION OF ANTAGONISTS OF CORTICOTROPIN-RELEASING FACTOR
Autore:
DEGREEF WJ; OOMS MP; VREEBURG JTM; WEBER RFA;
Indirizzi:
ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,DEPT ENDOCRINOL & REPROD,POB 1738 3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,FAC MED & HLTH SCI,DEPT INTERNAL MED 3 3000 DRROTTERDAM NETHERLANDS
Titolo Testata:
Neuroendocrinology
fascicolo: 1, volume: 61, anno: 1995,
pagine: 19 - 26
SICI:
0028-3835(1995)61:1<19:POLDH->2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOPHYSEAL PORTAL BLOOD; MALE-RATS BEARING; ADULT MALE-RATS; MEDIAN-EMINENCE; PROLACTIN SECRETION; ETHER STRESS; SERUM LH; PARAVENTRICULAR LESIONS; GONADOTROPIN-SECRETION; GROWTH-HORMONE;
Keywords:
CORTICOTROPIN RELEASING HORMONE; GONADOTROPINS; CORTICOTROPIN RELEASING HORMONE ANTAGONISTS; HYPERPROLACTINEMIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
W.J. Degreef et al., "PLASMA-LEVELS OF LUTEINIZING-HORMONE DURING HYPERPROLACTINEMIA - RESPONSE TO CENTRAL ADMINISTRATION OF ANTAGONISTS OF CORTICOTROPIN-RELEASING FACTOR", Neuroendocrinology, 61(1), 1995, pp. 19-26

Abstract

Since high concentrations of prolactin (PRL) enhance the hypothalamicrelease of corticotropin-releasing factor (CRF), and CRF decreases the hypothalamic secretion of luteinizing hormone (LH)-releasing hormone(LHRH), it could be that CRF is involved in the suppressed secretion of LH during hyperprolactinemia. The aim of this study was to explore this possibility in hyperprolactinemic male rats. Hyperprolactinemia, induced by insertion of 3 pituitary glands under the kidney capsule, decreased plasma LH levels by 68% and caused a 2-fold increase in plasma corticosterone. Intracisternal administration of the CRF antagonist alpha-helical CRF(9-41) induced both in pituitary-grafted rats and in normoprolactinemic controls a 2 to 3-fold increase of LH in the plasmasample taken 1 h after injection of alpha-helical CRF(9-41). Plasma levels of LH in pituitary-grafted rats were 2-3 times higher during intracerebroventricular infusion for 7 days with CRF antiserum than during saline infusion. Furthermore, after infusion of CRF antiserum for 7 days into the lateral brain ventricle plasma LH levels had increased by 270% in normoprolactinemic male rats. These results indicate that hypothalamic CRF is involved in the control of LH release in male rats. To further investigate whether CRF is involved in the effect of PRL onLH secretion, we infused PRL, alone or together with CRF antiserum, for 7 days into the lateral brain ventricle of normoprolactinemic male rats. After 7 days of PRL infusion, LH levels had decreased by 45%, whereas plasma corticosterone was 150% higher. This action of PRL on LH and corticosterone was prevented when besides PRL also CRF antiserum was infused. On the basis of these results it is suggested that the reduced secretion of LH and the increased secretion of corticosterone during hyperprolactinemia is at least partly due to a direct effect of PRL on the hypothalamus. Furthermore, hypothalamic CRF seems involved inthe control of LH secretion, and hyperprolactinemia may enhance the hypothalamic activity of CRF-producing neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:12:31