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Titolo:
A PUTATIVE MODEL OF THE DOPAMINE TRANSPORTER
Autore:
EDVARDSEN O; DAHL SG;
Indirizzi:
UNIV TROMSO,INST MED BIOL,DEPT PHARMACOL N-9037 TROMSO NORWAY UNIV TROMSO,INST MED BIOL,DEPT PHARMACOL N-9037 TROMSO NORWAY
Titolo Testata:
Molecular brain research
fascicolo: 2, volume: 27, anno: 1994,
pagine: 265 - 274
SICI:
0169-328X(1994)27:2<265:APMOTD>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN GABA TRANSPORTER; RAT-BRAIN; MOLECULAR-DYNAMICS; FUNCTIONAL EXPRESSION; SEROTONIN TRANSPORTER; CRYSTAL-STRUCTURE; CLONING; COCAINE; PROTEIN; RECEPTOR;
Keywords:
DOPAMINE; TRANSPORTER; COCAINE; 3-DIMENSIONAL STRUCTURE; MOLECULAR MODELING; MOLECULAR DYNAMICS; ELECTROSTATIC POTENTIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
O. Edvardsen e S.G. Dahl, "A PUTATIVE MODEL OF THE DOPAMINE TRANSPORTER", Molecular brain research, 27(2), 1994, pp. 265-274

Abstract

A three-dimensional model of the human dopamine transporter was constructed by molecular modeling techniques from its amino acid sequence, based on sequence analysis of this and 9 other transporter proteins. The model has 12 membrane spanning alpha-helices arranged in two 7-helical bundles, loops between helices and amino- and carboxy termini. Themolecular electrostatic potentials were mainly negative at the synaptic side and positive in the cytoplasmic domains of the transporter model, strongly positive in some of the transmembrane domains, and strongly negative in other transmembrane domains. The model suggests specific binding sites for dopamine and cocaine, a functional role for chloride ions, and accounts for known structure-activity relationships of cocaine analogs at the dopamine transporter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:38:43