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Titolo:
CHANGES IN GLUCOSE-METABOLISM FROM DISCRETE REGIONS OF RAT-BRAIN AND ITS RELATIONSHIP TO REPRODUCTIVE FAILURE DURING EXPERIMENTAL DIABETES
Autore:
LAKHMAN SS; SHARMA P; KAUR G; KAUR G;
Indirizzi:
GURU NANAK DEV UNIV,DEPT BIOTECHNOL,NEUROENDOCRINOL & NEUROCHEM LAB AMRITSAR 143005 PUNJAB INDIA GURU NANAK DEV UNIV,DEPT BIOTECHNOL,NEUROENDOCRINOL & NEUROCHEM LAB AMRITSAR 143005 PUNJAB INDIA
Titolo Testata:
Molecular and cellular biochemistry
fascicolo: 2, volume: 141, anno: 1994,
pagine: 97 - 102
SICI:
0300-8177(1994)141:2<97:CIGFDR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; ENERGY-METABOLISM; FUNCTIONAL-ACTIVITY; BLOOD; TRANSPORTER; MELLITUS; CARBOHYDRATE; NUCLEUS; ANIMALS; TISSUES;
Keywords:
HYPERGLYCEMIA; HEXOKINASE; LACTATE DEHYDROGENASE; GLUCOSE-6-PHOSPHATE DEHYDROGENASE; REPRODUCTION; INSULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S.S. Lakhman et al., "CHANGES IN GLUCOSE-METABOLISM FROM DISCRETE REGIONS OF RAT-BRAIN AND ITS RELATIONSHIP TO REPRODUCTIVE FAILURE DURING EXPERIMENTAL DIABETES", Molecular and cellular biochemistry, 141(2), 1994, pp. 97-102

Abstract

This study reports the effects of alloxan induced diabetes on glucosemetabolism enzymes viz. Hexokinase, Lactate dehydrogenase, and Glucose-6-phosphate dehydrogenase from discrete brain regions. Enzymes activity was assayed from hypothalamic areas such as medial preoptic area and median eminence-arcuate region which have gonadotropin releasing hormone cell bodies and their terminals, respectively and other brain regions like septum, amygdala, hippocampus, and thalamus. In all the areas studied, induction of diabetes resulted in a significant decrease in particulate bound HK activity, whereas soluble HK, LDH and G6PDH activity showed increase at 3, 8, 15 and 28 days intervals. Insulin treatment of diabetic rats led to recovery in enzyme activity. Blood glucose levels increased significantly after induction of diabetes and recovery was seen after insulin treatment. The present results suggest thataltered cerebral glucose metabolism may also be responsible for reproductive failure observed in diabetic rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 15:20:35