Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INCREASED EXPRESSION OF CYCLIN D1 IN THE ADULT-RAT BRAIN FOLLOWING KAINIC ACID TREATMENT
Autore:
LIU W; BI XN; TOCCO G; BAUDRY M; SCHREIBER SS;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT NEUROL,1333 SAN PABLO ST,MCH 142 LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT NEUROL LOS ANGELES CA 90033 UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
NeuroReport
fascicolo: 15-17, volume: 7, anno: 1996,
pagine: 2785 - 2789
SICI:
0959-4965(1996)7:15-17<2785:IEOCDI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR PROTEIN; NEURONAL DAMAGE; P53 INDUCTION; CELL-DEATH; APOPTOSIS; IDENTIFICATION; ACCUMULATION; G(1)-CYCLINS; FIBROBLASTS;
Keywords:
APOPTOSIS; CELL CYCLE; CYCLINS; EXCITOTOXICITY; NEURONAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
W. Liu et al., "INCREASED EXPRESSION OF CYCLIN D1 IN THE ADULT-RAT BRAIN FOLLOWING KAINIC ACID TREATMENT", NeuroReport, 7(15-17), 1996, pp. 2785-2789

Abstract

RECENT evidence has implicated aberrant cell cycle regulation as a possible mechanism of apoptosis in nondividing cells. We previously demonstrated increased expression of the p53 tumor suppressor gene, a prominent cell cycle regulator, in apoptotic neurons. Here we investigatedthe potential involvement of cyclin D1, a G1 phase cell cycle proteinunder p53 regulation, in kainic acid-mediated neuronal degeneration. Adult male Sprague-Dawley rats were treated systemically with kainic acid and sacrificed between 1 h and 5 days following seizure onset. Cyclin D1 expression was studied by Western blot analysis and immunohistochemistry using a rabbit polyclonal anti-cyclin D1 antibody. In untreated control rats low levels of cyclin D1 expression were detected in multiple brain regions. Between 8 and 16 h after the onset of kainic acid-induced seizures, increased cyclin D1 immunoreactivity was observedin vulnerable hippocampal pyramidal cells. Five days after seizure onset increased cyclin D1 expression was evident in reactive astrocytes. These results support a role for cyclin D1 in certain neuronal death pathways, and suggest that cyclin D1 has multiple and cell type-specific functions in the central nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:56:36