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Titolo:
NUMBER AND SIZE OF RENAL GLOMERULI IN SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
SKOV K; NYENGAARD JR; KORSGAARD N; MULVANY MJ;
Indirizzi:
AARHUS KOMMUNE HOSP,DEPT PATHOL,NORREBROGADE 1 DK-8000 AARHUS C DENMARK AARHUS UNIV HOSP,AARHUS CITY HOSP,DEPT PATHOL AARHUS DENMARK AARHUS UNIV,DEPT PHARMACOL AARHUS DENMARK AARHUS UNIV,STEREOL RES LAB AARHUS DENMARK
Titolo Testata:
Journal of hypertension
fascicolo: 12, volume: 12, anno: 1994,
pagine: 1373 - 1376
SICI:
0263-6352(1994)12:12<1373:NASORG>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-RESISTANCE; SALT INTAKE; KIDNEY; STEREOLOGY; FRACTIONATOR; PROTEINURIA; ETIOLOGY; PRESSURE; STRAIN; AGE;
Keywords:
SPONTANEOUSLY HYPERTENSIVE RAT; KIDNEY; GLOMERULI; QUANTITATIVE METHODS; STEREOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
K. Skov et al., "NUMBER AND SIZE OF RENAL GLOMERULI IN SPONTANEOUSLY HYPERTENSIVE RATS", Journal of hypertension, 12(12), 1994, pp. 1373-1376

Abstract

Objective: A reduced number of nephrons, whether acquired or congenital, as has been observed in certain inbred rat strains, may lead to systemic hypertension. The present study estimated the total number of glomeruli and mean glomerular size in kidneys of spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Methods: Unbiased stereological methods were used on immersion-fixed kidneys from 12-week-old male SHR (n = 9) and age-matched WKY rats (n = 11). Results: The total number of glomeruli was significantly reduced in the SHR compared with in the WKY rats. Sclerotic glomeruli were not found in either group. No significant difference in mean glomerular volume was observed, but the total glomerular volume was reduced by 25% in the SHRcompared with in the WKY rats. Conclusion: SHR have fewer glomeruli than WKY rats, but of similar size, resulting in a reduced total glomerular volume in adult SHR. These findings are consistent with the hypothesis that the kidney plays an important role in the pathogenesis of genetic hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:16:56