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Titolo:
RAT ASTROGLIAL P2Z (P2X(7)) RECEPTORS REGULATE INTRACELLULAR CALCIUM AND PURINE RELEASE
Autore:
BALLERINI P; RATHBONE MP; DIIORIO P; RENZETTI A; GIULIANI P; DALIMONTE I; TRUBIANI O; CACIAGLI F; CICCARELLI R;
Indirizzi:
MCMASTER UNIV,HLTH SCI CTR,DEPT BIOMED SCI,4N25,1200 MAIN ST W HAMILTON ON L8N 3Z5 CANADA MCMASTER UNIV,HLTH SCI CTR,DEPT BIOMED SCI HAMILTON ON L8N 3Z5 CANADA MCMASTER UNIV,HLTH SCI CTR,DEPT MED HAMILTON ON L8N 3Z5 CANADA UNIV CHIETI,INST PHARMACOL & BIOMED TECHNOL CHIETI ITALY UNIV CHIETI,INST HUMAN MORPHOL CHIETI ITALY
Titolo Testata:
NeuroReport
fascicolo: 15-17, volume: 7, anno: 1996,
pagine: 2533 - 2537
SICI:
0959-4965(1996)7:15-17<2533:RAP(RR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISSOCIATED PRIMARY CULTURES; OXIDIZED ATP; GLIAL-CELLS; MACROPHAGES; ASTROCYTES; MODULATION; INHIBITION; RESPONSES; ENZYME; BRAIN;
Keywords:
PRIMARY ASTROGLIAL CULTURES; EXTRACELLULAR PURINES; PURINOCEPTORS; P2X(7) (P2Z) SUBTYPE; MEMBRANE PERMEABILIZATION; [CA2+](I) LEVELS; [H-3] PURINE RELEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P. Ballerini et al., "RAT ASTROGLIAL P2Z (P2X(7)) RECEPTORS REGULATE INTRACELLULAR CALCIUM AND PURINE RELEASE", NeuroReport, 7(15-17), 1996, pp. 2533-2537

Abstract

TREATMENT Of rat astrocyte cultures with 2'- and 3'-O-(4-benzoylbenzoyl)-adenosine 5'-triphosphate (BzATP), a P2X(7) agonist, but not with adenosine 5-[alpha beta methylene] triphosphate (alpha,beta meATP), a P2X agonist, increased influx of extracellular Ca2+ and [Ca2+](i). Lucifer yellow, a small molecule which permeates P2X(7) receptor-induced pores, entered BzATP-treated but not control astrocytes. BzATP also stimulated efflux of [H-3]purine from cultured astrocytes. The P2X(7) receptor antagonist oxidized ATP abolished the effects of BzATP on [Ca2+](i) lucifer yellow permeation and [H-3]purine release, indicating that these effects were due to P2X(7) receptor activation. In neurological diseases or injuries extracellular ATP may activate P2X(7) receptorsfurther enhancing [H-3]purine release, with important pathophysiological consequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:29:14