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Titolo:
DIFFERENTIAL RECEPTIVE AND EXPRESSIVE LANGUAGE FUNCTIONING OF CHILDREN WITH SYMPTOMATIC HIV DISEASE AND RELATION TO CT SCAN BRAIN ABNORMALITIES
Autore:
WOLTERS PL; BROUWERS P; MOSS HA; PIZZO PA;
Indirizzi:
NCI,PEDIAT BRANCH,NEUROPSYCHOL GRP,BLDG 10,13N240,10 CTR DR,MSC 1928 BETHESDA MD 20892 MED ILLNESS COUNSELING CTR CHEVY CHASE MD 00000
Titolo Testata:
Pediatrics
fascicolo: 1, volume: 95, anno: 1995,
pagine: 112 - 119
SICI:
0031-4005(1995)95:1<112:DRAELF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; INFUSION ZIDOVUDINE THERAPY; IMMUNE-DEFICIENCY SYNDROME; DEVELOPMENTAL ABNORMALITIES; PROGRESSIVE ENCEPHALOPATHY; BASAL GANGLIA; SYNDROME AIDS; INFANTS; INFECTION; GROWTH;
Keywords:
PEDIATRIC AIDS; HIV INFECTION; NEUROPSYCHOLOGY; LANGUAGE; ENCEPHALOPATHY CT SCAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
P.L. Wolters et al., "DIFFERENTIAL RECEPTIVE AND EXPRESSIVE LANGUAGE FUNCTIONING OF CHILDREN WITH SYMPTOMATIC HIV DISEASE AND RELATION TO CT SCAN BRAIN ABNORMALITIES", Pediatrics, 95(1), 1995, pp. 112-119

Abstract

Objectives. To investigate the effect of HIV disease on the receptiveand expressive language of children and the relationship between CT scan brain abnormalities and language functioning. Methods. Thirty-six children (mean age, 5.5 years; range, 1 through 10 years; 75% verticaltransmission; 58% classified as encephalopathic) with symptomatic HIVinfection and 20 uninfected siblings (mean age, 7.8 years; range, 3 through 15 years) were administered an age-appropriate comprehensive language test assessing both receptive and expressive language (Reynell Developmental Language Scales or Clinical Evaluation of Language Fundamentals-Revised). Each HIV-infected child had a CT scan of the brain as part of the baseline evaluation, which was rated independently and blindly by two neurologists, for presence and severity of brain abnormalities using a semiquantitative rating system. Results. Expressive language was significantly more impaired than receptive language in the overall sample of HIV-infected children. The encephalopathic children scored significantly lower than the non-encephalopathic children, however, the degree of discrepancy between mean receptive and expressive language scores was not significantly different between these two groups. The uninfected sibling control group did not have a significant discrepancy between receptive and expressive language, and they scored significantly higher than the infected patient group. Greater severity ofCT scan abnormalities was significantly correlated with poorer receptive and expressive language functioning in the overall HIV-infected sample and a higher discrepancy between receptive and expressive language in the encephalopathic group. Conclusion. Pediatric HIV disease is associated with differential receptive and expressive language functioning in which expressive language is significantly more impaired than receptive language. The sibling data and CT scan correlations suggest that the observed language impairments are associated with the direct effects of HIV-related central nervous system disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:38:59