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Titolo:
TRANSITIONAL-CELL CARCINOMA OF THE RENAL PELVIS AND ITS EXPRESSION OFP53 PROTEIN, C-ERBB-2 PROTEIN, NEURON-SPECIFIC ENOLASE, PHE-5, CHROMOGRANIN, LAMININ AND COLLAGEN TYPE-IV
Autore:
BJERKEHAGEN B; FOSSA SD; RAABE N; HOLM R; NESLAND JM;
Indirizzi:
NORWEGIAN RADIUM HOSP,DEPT PATHOL N-0310 OSLO NORWAY NORWEGIAN RADIUM HOSP,DEPT RADIOTHERAPY & ONCOL N-0310 OSLO NORWAY
Titolo Testata:
European urology
fascicolo: 4, volume: 26, anno: 1994,
pagine: 334 - 339
SICI:
0302-2838(1994)26:4<334:TCOTRP>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASEMENT-MEMBRANE MARKERS; URINARY-BLADDER; BREAST CARCINOMAS; CANCER; ONCOGENE; TUMORS; AMPLIFICATION; MUTATIONS; RECEPTOR; PRODUCT;
Keywords:
RENAL PELVIC CARCINOMA; IMMUNOHISTOCHEMISTRY; C-ERBB-2 PROTEIN; P53 PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
B. Bjerkehagen et al., "TRANSITIONAL-CELL CARCINOMA OF THE RENAL PELVIS AND ITS EXPRESSION OFP53 PROTEIN, C-ERBB-2 PROTEIN, NEURON-SPECIFIC ENOLASE, PHE-5, CHROMOGRANIN, LAMININ AND COLLAGEN TYPE-IV", European urology, 26(4), 1994, pp. 334-339

Abstract

Expression of p53 protein, c-erbB-2 protein, neuron-specific enolase (NSE), Phe 5, chromogranin, laminin and collagen type IV was studied by immunohistochemistry in formalin-fixed and paraffin-embedded specimens from 20 patients with renal pelvic carcinoma. Positive membrane-bound c-erbB-2 staining was not found in any case. Two tumors stained forp53 protein. Focal immunoreactivity for laminin was present in 55% and for collagen type IV in 80%. 25% of the cases were NSE positive. None of the tumors stained for Phe 5 or chromogranin. The results were compared with the clinical outcome and the immunohistological findings of p53 protein and c-erbB-2 protein in 13 cases of bladder carcinoma inthe same patient group. Four of the thirteen bladder cancer specimens, but only 2 of the 20 renal pelvic cancer specimens, expressed p53 protein. As for renal pelvic carcinoma, c-erbB-2 protein was not expressed in bladder carcinoma. We conclude that p53 gene abnormalities may be of importance in the development of carcinoma in the renal pelvis and urinary bladder, but c-erbB-2 protein expression does not play a major role.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 02:26:59