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Titolo:
ANTIBODY TO HIV-1 TAT PROTEIN INHIBITS THE REPLICATION OF VIRUS IN CULTURE
Autore:
STEINAA L; SORENSEN AM; NIELSEN JO; HANSEN JES;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS 144 DK-2650 HVIDOVRE DENMARK
Titolo Testata:
Archives of virology
fascicolo: 3-4, volume: 139, anno: 1994,
pagine: 263 - 271
SICI:
0304-8608(1994)139:3-4<263:ATHTPI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; TRANS-ACTIVATOR GENE; LONG TERMINAL REPEAT; RNA-SYNTHESIS; HTLV-III; BINDING; TYPE-1; AIDS; TRANSACTIVATION; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
L. Steinaa et al., "ANTIBODY TO HIV-1 TAT PROTEIN INHIBITS THE REPLICATION OF VIRUS IN CULTURE", Archives of virology, 139(3-4), 1994, pp. 263-271

Abstract

The HIV-1 transactivator protein Tat is essential for viral replication. Tat is released from infected cells and can be taken up and transactivate HIV-LTR in LTR-CAT transfected cell lines. The present study shows that the addition of monoclonal antibody to Tat in IIIB and MN-infected cultures reduces the HIV antigen production in a concentration dependent manner. These data suggest that external Tat might be important in the replication of HIV, exerting the effect in a paracrine fashion. Using 1 mu g/ml of anti-Tat antibody resulted in a decline of HIVantigen production to 33% and 45% of controls in IIIB and MN infectedH9 cells, respectively. A time course experiment showed progressivelyincreased inhibition of replication during 7 days of exposure to anti-Tat antibody, which could be due to increasing Tat concentration. Theinhibitory effect of anti-Tat antibodies on the replication of HIV could play an important regulatory role during infection in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 04:51:32