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Titolo:
PLASMA LIPOPROTEIN(A) LEVELS AND FIBRINOLYTIC-ACTIVITY IN ACUTE MYOCARDIAL-INFARCTION
Autore:
HONDA Y; OSHIMA S; OGAWA H; SAKAMOTO T; MIYAO Y; SAKATA S; HIRASHIMA O; MORIYAMA Y; YASUE H;
Indirizzi:
KUMAMOTO UNIV,SCH MED,DIV CARDIOL,1-1-1 HONJO KUMAMOTO 860 JAPAN KUMAMOTO UNIV,SCH MED,DIV CARDIOL KUMAMOTO 860 JAPAN FUKUOKA TOKUSHUKAI HOSP,DIV CARDIOL FUKUOKA JAPAN
Titolo Testata:
Japanese Circulation Journal
fascicolo: 12, volume: 58, anno: 1994,
pagine: 869 - 876
SICI:
0047-1828(1994)58:12<869:PLLAFI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; UNSTABLE ANGINA-PECTORIS; ALPHA-2-PLASMIN INHIBITOR; LP(A) LIPOPROTEIN; CORONARY-ARTERY; ASSOCIATION; BINDING; PATENCY; ASSAY; ATHEROSCLEROSIS;
Keywords:
LIPOPROTEIN (A); PLASMINOGEN ACTIVATOR INHIBITOR; ALPHA 2-PLASMIN INHIBITOR-PLASMIN COMPLEX; THROMBIN ANTITHROMBIN III COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
Y. Honda et al., "PLASMA LIPOPROTEIN(A) LEVELS AND FIBRINOLYTIC-ACTIVITY IN ACUTE MYOCARDIAL-INFARCTION", Japanese Circulation Journal, 58(12), 1994, pp. 869-876

Abstract

To evaluate the effects of lipoprotein (a) [Lp (a)] on the fibrinolytic system in patients with acute myocardial infarction (AMI) who underwent thrombolytic therapy with recombinant tissue-type plasminogen activator, we examined serial changes in plasma levels of Lp (a), plasminogen activator inhibitor (PAI) activity, alpha 2-plasmin inhibitor-plasmin complex (PIC) and thrombin antithrombin III complex (TAT) in venous plasma samples from 25 patients with AMI for 3 weeks. Plasma Lp (a)levels were significantly increased 5, 7, and 14 days after admissionand tended to decrease by the 21st day. On the other hand, the ratio of PIC/TAT was significantly increased on the 7th day and remained high for 3 weeks (p<0.01), while plasma PAI activity was significantly decreased on the 5th day after admission (p<0.01). Thus, plasma fibrinolytic function is impaired in the early phase after AMI, and gradually improves over the course of 3 weeks. The increase in plasma Lp (a) levels is, therefore, not accompanied by a significant decrease in plasmafibrinolytic function in patients with AMI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 11:36:50