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Titolo:
AUTOANTIBODIES TO DESMOPLAKIN-I AND DESMOPLAKIN-II IN PATIENTS WITH ERYTHEMA-MULTIFORME
Autore:
FOEDINGER D; ANHALT GJ; BOECSKOER B; ELBE A; WOLFF K; RAPPERSBERGER K;
Indirizzi:
UNIV VIENNA,SCH MED,VIENNA INT RES COOPERAT CTR,DEPT DERMATOL,DIV GENDERMATOL A-1090 VIENNA AUSTRIA UNIV VIENNA,SCH MED,VIENNA INT RES COOPERAT CTR,DEPT DERMATOL,DIV GENDERMATOL A-1090 VIENNA AUSTRIA UNIV VIENNA,SCH MED,VIENNA INT RES COOPERAT CTR,DIV IMMUNOL ALLERGY &INFECT DIS A-1090 VIENNA AUSTRIA JOHNS HOPKINS UNIV,DEPT DERMATOL,DIV DERMATOIMMUNOL BALTIMORE MD 21205
Titolo Testata:
The Journal of experimental medicine
fascicolo: 1, volume: 181, anno: 1995,
pagine: 169 - 179
SICI:
0022-1007(1995)181:1<169:ATDADI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BULLOUS PEMPHIGOID ANTIGEN; INTERMEDIATE FILAMENT NETWORKS; PARANEOPLASTIC PEMPHIGUS; DESMOSOMAL PLAQUE; CELL-ADHESION; ANTIBODY; FOLIACEUS; ORGANIZATION; VULGARIS; PROTEINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D. Foedinger et al., "AUTOANTIBODIES TO DESMOPLAKIN-I AND DESMOPLAKIN-II IN PATIENTS WITH ERYTHEMA-MULTIFORME", The Journal of experimental medicine, 181(1), 1995, pp. 169-179

Abstract

Erythema multiforme (EM) represents a syndrome of chronic recurrent inflammatory skin disease. Depending on the severity and extent of skinand mucosal involvement, it is defined either as EM minor or EM major. In this study we demonstrate the presence of autoantibodies (aAbs) against desmoplakin I and II, two major proteins of the desmosomal plaque, in six of six patients with the severe variant of EM, EM major. Light microscopic studies of lesional skin and mucous membranes localized in vivo bound immunoglobulin G (IgG) in a dotted desmosomal pattern along the cytoplasmic membranes of keratinocytes. By immunoelectronmicroscopy, in vivo bound IgG was confined to the desmosomal plaques. These findings were confirmed by indirect immunolocalization studies thatdemonstrated the presence of IgG aAbs in the serum of patients duringactive disease. These aAbs did not only bind to desmosomal plaques ofepithelial cells where they colocalized with defined murine monoclonal antibodies directed against desmoplakin I and II, but also labeled the intercalated discs of myocardial cells. Biochemical characterization of circulating IgG aAbs revealed desmoplakin I and II as actual target autoantigens. By passive transfer of serum into newborn mice, in vivo binding of serum aAbs to keratinocytes was shown. The findings presented in this study imply a humoral immune response in certain patients with EM major and indicate a potential pathogenetic role of aAbs against desmoplakin I and II in this disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 07:00:59