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Titolo:
ALLOGENEIC RESPONSES OF HUMAN UMBILICAL-CORD BLOOD
Autore:
RISDON G; GADDY J; BROXMEYER HE;
Indirizzi:
INDIANA UNIV,SCH MED,WALTHER ONCOL CTR,975 W WALNUT ST,ROOM 501 INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,WALTHER ONCOL CTR INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT MED HEMATOL ONCOL INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL INDIANAPOLIS IN 46202
Titolo Testata:
Blood cells
fascicolo: 2-3, volume: 20, anno: 1994,
pagine: 566 - 572
SICI:
0340-4684(1994)20:2-3<566:AROHUB>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM; LYMPHOCYTES-T; CELLS; TRANSPLANTATION; PATIENT;
Keywords:
ALLOGENEIC RESPONSE; HUMAN UMBILICAL CORD BLOOD; GRAFT VS HOST DISEASE; MONONUCLEAR CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
G. Risdon et al., "ALLOGENEIC RESPONSES OF HUMAN UMBILICAL-CORD BLOOD", Blood cells, 20(2-3), 1994, pp. 566-572

Abstract

Human umbilical cord blood (CB) is increasingly used as an alternative to bone marrow as a source of stem and progenitor cells for pediatric patients. We have evaluated the alloreactive potential of cord bloodT cells in vitro. Our findings demonstrate that in a primary mixed leukocyte culture CB T cells demonstrate strong proliferative responses to allogeneic stimulation but little to no generation of cytotoxic effector function, Furthermore, restimulation of primary cultures resultsin a state of proliferative unresponsiveness. Such diminished cytotoxic and proliferative responses may, in part, be related to the low incidence of graft vs. host disease thus far noted in human CB transplants,

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 04:59:38