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Titolo:
RETENTION AND MULTILINEAGE EXPRESSION OF HUMAN HEMATOPOIETIC STEM-CELLS IN HUMAN SHEEP CHIMERAS
Autore:
ZANJANI ED; SILVA MRG; FLAKE AW;
Indirizzi:
VET ADM MED CTR,151B,1000 LOCUST ST RENO NV 89511 UNIV NEVADA,SCH MED,DEPT VET AFFAIRS MED CTR RENO NV 89557
Titolo Testata:
Blood cells
fascicolo: 2-3, volume: 20, anno: 1994,
pagine: 331 - 340
SICI:
0340-4684(1994)20:2-3<331:RAMEOH>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TERM INVITRO HEMATOPOIESIS; IMMUNE-DEFICIENT MICE; BONE-MARROW STROMA; PROGENITOR CELLS; SELF-RENEWAL; ENGRAFTMENT; INUTERO; DIFFERENTIATION; TRANSPLANTATION; IDENTIFICATION;
Keywords:
HEMATOPOIETIC STEM CELLS; XENOGENEIC TRANSPLANTATION; IN UTERO TRANSPLANTATION; HUMAN SHEEP XENOGRAFT; HEMATOPOIETIC STEM CELL ASSAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
E.D. Zanjani et al., "RETENTION AND MULTILINEAGE EXPRESSION OF HUMAN HEMATOPOIETIC STEM-CELLS IN HUMAN SHEEP CHIMERAS", Blood cells, 20(2-3), 1994, pp. 331-340

Abstract

We have taken advantage of the permissive environment of the preimmune fetus to achieve engraftment of hematopoietic stem cells (HSC) from fetal and postnatal human sources in sheep, The resulting chimeric lambs exhibited long-term multilineage (erythroid, myeloid, lymphoid) expression of donor cells that remained responsive to human-specific cytokines, The small size of the fetus allowed the assessment of the engraftment potential of relatively small numbers of highly characterized human HSC populations, while the large size of the chimeric sheep permitted the long-term evaluation of the HSC activity and response in vivo. The human/sheep xenograft may offer a useful large animal model for the assay and long-term study of the human HSC subsets,

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:08:16