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Titolo:
UNRELATED, HLA-MISMATCHED MULTIPLE HUMAN UMBILICAL-CORD BLOOD-TRANSFUSION IN 4 CASES WITH ADVANCED SOLID TUMORS - INITIAL STUDIES
Autore:
SHEN BJ; HOU HS; ZHANG HQ; SUI XW;
Indirizzi:
SHANDONG MED UNIV,AFFILIATED HOSP,DEPT PEDIAT SHANDONG 250012 PEOPLESR CHINA SHANDONG MED UNIV,AFFILIATED HOSP,CRYOMED LAB SHANDONG 250012 PEOPLESR CHINA
Titolo Testata:
Blood cells
fascicolo: 2-3, volume: 20, anno: 1994,
pagine: 285 - 292
SICI:
0340-4684(1994)20:2-3<285:UHMHUB>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMATOPOIETIC STEM; LYMPHOCYTES-T; CELLS; TRANSPLANTATION;
Keywords:
MULTIPLE HUMAN UMBILICAL CORD BLOOD TRANSFUSION; HLA MISMATCHED; HEMATOPOIETIC RECONSTITUTION; SIMULTANEOUS ENGRAFTMENT OF CORD BLOOD STEM CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
B.J. Shen et al., "UNRELATED, HLA-MISMATCHED MULTIPLE HUMAN UMBILICAL-CORD BLOOD-TRANSFUSION IN 4 CASES WITH ADVANCED SOLID TUMORS - INITIAL STUDIES", Blood cells, 20(2-3), 1994, pp. 285-292

Abstract

Four patients with advanced solid tumors were treated by means of high-dose chemotherapy and HLA-mismatched and unrelated multi-cord blood transfusion. Of these patients, three achieved complete remission and one achieved a partial remission, Little or no graft vs, host disease (GVHD) was observed, Partial donor cell engraftment was suggested by 101 to 320 days for two patients by cytogenetic analysis and hemoglobinF levels in the peripheral blood. Recurrent disease was confirmed clinically on day 210 (4-year-old girl with liposarcoma) and on day 90 (11-year-old boy with non-Hodgkin's lymphoma). These results suggest thepossibility that HLA-mismatched and unrelated multi-cord blood transfusion may engraft with little or no GVHD and hasten recovery from marrow suppression that is due to chemotherapy. It remains to be determined, however, whether these results document true stem/progenitor tell engraftment or alternatively transient engraftment of more mature cellsalong with repopulation by autologous cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:24:58